| Reaction Details |
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 | Report a problem with these data |
| Target | TYR_PHOSPHATASE_2 domain-containing protein |
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| Ligand | BDBM50522532 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1886957 (CHEMBL4388634) |
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| IC50 | 46000±n/a nM |
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| Citation |  Washburn, A; Abdeen, S; Ovechkina, Y; Ray, AM; Stevens, M; Chitre, S; Sivinski, J; Park, Y; Johnson, J; Hoang, QQ; Chapman, E; Parish, T; Johnson, SM Dual-targeting GroEL/ES chaperonin and protein tyrosine phosphatase B (PtpB) inhibitors: A polypharmacology strategy for treating Mycobacterium tuberculosis infections. Bioorg Med Chem Lett29:1665-1672 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| TYR_PHOSPHATASE_2 domain-containing protein |
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| Name: | TYR_PHOSPHATASE_2 domain-containing protein |
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| Synonyms: | (PROTEIN-TYROSINE-PHOSPHATASE) (PTPase) | MPtpB | PHOSPHOTYROSINE PROTEIN PHOSPHATASE PTPB | Phosphotyrosine protein phosphatase | Phosphotyrosine-protein phosphatase PTPB | Protein Tyrosine Phosphatase PTPB |
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| Type: | Hydrolase |
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| Mol. Mass.: | 30152.45 |
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| Organism: | Mycobacterium tuberculosis |
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| Description: | n/a |
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| Residue: | 276 |
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| Sequence: | MAVRELPGAWNFRDVADTATALRPGRLFRSSELSRLDDAGRATLRRLGITDVADLRSSRE
VARRGPGRVPDGIDVHLLPFPDLADDDADDSAPHETAFKRLLTNDGSNGESGESSQSIND
AATRYMTDEYRQFPTRNGAQRALHRVVTLLAAGRPVLTHCFAGKDRTGFVVALVLEAVGL
DRDVIVADYLRSNDSVPQLRARISEMIQQRFDTELAPEVVTFTKARLSDGVLGVRAEYLA
AARQTIDETYGSLGGYLRDAGISQATVNRMRGVLLG
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| BDBM50522532 |
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| n/a |
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| Name | BDBM50522532 |
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| Synonyms: | CHEMBL4532359 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H18N2O3S |
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| Mol. Mass. | 378.444 |
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| SMILES | CCc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)-c1nc2ccccc2o1 |
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| Structure | 
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