| Reaction Details |
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 | Report a problem with these data |
| Target | Malate dehydrogenase, mitochondrial |
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| Ligand | BDBM50522572 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1886964 (CHEMBL4388641) |
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| IC50 | >63000±n/a nM |
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| Citation |  Washburn, A; Abdeen, S; Ovechkina, Y; Ray, AM; Stevens, M; Chitre, S; Sivinski, J; Park, Y; Johnson, J; Hoang, QQ; Chapman, E; Parish, T; Johnson, SM Dual-targeting GroEL/ES chaperonin and protein tyrosine phosphatase B (PtpB) inhibitors: A polypharmacology strategy for treating Mycobacterium tuberculosis infections. Bioorg Med Chem Lett29:1665-1672 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Malate dehydrogenase, mitochondrial |
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| Name: | Malate dehydrogenase, mitochondrial |
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| Synonyms: | MDH2 | MDHM_PIG | Malate dehydrogenase mitochondrial |
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| Type: | Oxidoreductase; homodimer |
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| Mol. Mass.: | 35493.48 |
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| Organism: | Sus scrofa (pig) |
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| Description: | Porcine heart mitochondria. |
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| Residue: | 337 |
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| Sequence: | MLSALARPAGAALRRSFSTSQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHT
PGVAADLSHIETRATVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIV
ATLTAACAQHCPDAMICIISNPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANAFV
AELKGLDPARVSVPVIGGHAGKTIIPLISQCTPKVDFPQDQLSTLTGRIQEAGTEVVKAK
AGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQETDCPYFSTPLLLGKKGIEK
NLGIGKISPFEEKMIAEAIPELKASIKKGEEFVKNMK
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| BDBM50522572 |
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| n/a |
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| Name | BDBM50522572 |
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| Synonyms: | CHEMBL4542758 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H12N2O3S2 |
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| Mol. Mass. | 356.419 |
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| SMILES | O=S(=O)(Nc1ccc(cc1)-c1nc2ccccc2o1)c1cccs1 |
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| Structure | 
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