| Reaction Details |
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 | Report a problem with these data |
| Target | 60 kDa heat shock protein, mitochondrial |
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| Ligand | BDBM50522556 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1886967 (CHEMBL4388644) |
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| IC50 | 50000±n/a nM |
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| Citation |  Washburn, A; Abdeen, S; Ovechkina, Y; Ray, AM; Stevens, M; Chitre, S; Sivinski, J; Park, Y; Johnson, J; Hoang, QQ; Chapman, E; Parish, T; Johnson, SM Dual-targeting GroEL/ES chaperonin and protein tyrosine phosphatase B (PtpB) inhibitors: A polypharmacology strategy for treating Mycobacterium tuberculosis infections. Bioorg Med Chem Lett29:1665-1672 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 60 kDa heat shock protein, mitochondrial |
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| Name: | 60 kDa heat shock protein, mitochondrial |
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| Synonyms: | 3.6.4.9 | 60 kDa chaperonin | 60 kDa heat shock protein, mitochondrial | CH60_HUMAN | CPN60 | Chaperonin 60 | HSP-60 | HSP60 | HSP60/HSP10 | HSPD1 | Heat shock protein 60 | HuCHA60 | Mitochondrial matrix protein P1 | P60 lymphocyte protein |
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| Type: | PROTEIN |
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| Mol. Mass.: | 61050.41 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_117701 |
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| Residue: | 573 |
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| Sequence: | MLRLPTVFRQMRPVSRVLAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGR
TVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLA
RSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDK
EIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQ
DAYVLLSEKKISSIQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAV
KAPGFGDNRKNQLKDMAIATGGAVFGEEGLTLNLEDVQPHDLGKVGEVIVTKDDAMLLKG
KGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDR
VTDALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIA
KNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLT
TAEVVVTEIPKEEKDPGMGAMGGMGGGMGGGMF
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| BDBM50522556 |
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| n/a |
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| Name | BDBM50522556 |
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| Synonyms: | CHEMBL4583096 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H13F3N2O3S |
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| Mol. Mass. | 418.389 |
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| SMILES | FC(F)(F)c1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)-c1nc2ccccc2o1 |
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| Structure | 
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