| Reaction Details |
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 | Report a problem with these data |
| Target | Endoplasmic reticulum chaperone BiP |
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| Ligand | BDBM31712 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1887316 (CHEMBL4388993) |
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| IC50 | 9100±n/a nM |
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| Citation |  Ambrose, AJ; Zerio, CJ; Sivinski, J; Schmidlin, CJ; Shi, T; Ross, AB; Widrick, KJ; Johnson, SM; Zhang, DD; Chapman, E A high throughput substrate binding assay reveals hexachlorophene as an inhibitor of the ER-resident HSP70 chaperone GRP78. Bioorg Med Chem Lett29:1689-1693 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Endoplasmic reticulum chaperone BiP |
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| Name: | Endoplasmic reticulum chaperone BiP |
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| Synonyms: | 3.6.4.10 | 78 kDa glucose-regulated protein | BIP_HUMAN | BiP | Binding-immunoglobulin protein | Endoplasmic reticulum chaperone BiP | Endoplasmic reticulum lumenal Ca(2+)-binding protein grp78 | GRP-78 | GRP78 | HSP70 family protein 5 | HSPA5 | Heat shock 70 kDa protein 5 | Heat shock protein 70 family protein 5 | Heat shock protein family A member 5 | Immunoglobulin heavy chain-binding protein | Synonyms=GRP78 |
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| Type: | n/a |
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| Mol. Mass.: | 72312.92 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11021 |
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| Residue: | 654 |
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| Sequence: | MKLSLVAAMLLLLSAARAEEEDKKEDVGTVVGIDLGTTYSCVGVFKNGRVEIIANDQGNR
ITPSYVAFTPEGERLIGDAAKNQLTSNPENTVFDAKRLIGRTWNDPSVQQDIKFLPFKVV
EKKTKPYIQVDIGGGQTKTFAPEEISAMVLTKMKETAEAYLGKKVTHAVVTVPAYFNDAQ
RQATKDAGTIAGLNVMRIINEPTAAAIAYGLDKREGEKNILVFDLGGGTFDVSLLTIDNG
VFEVVATNGDTHLGGEDFDQRVMEHFIKLYKKKTGKDVRKDNRAVQKLRREVEKAKRALS
SQHQARIEIESFYEGEDFSETLTRAKFEELNMDLFRSTMKPVQKVLEDSDLKKSDIDEIV
LVGGSTRIPKIQQLVKEFFNGKEPSRGINPDEAVAYGAAVQAGVLSGDQDTGDLVLLDVC
PLTLGIETVGGVMTKLIPRNTVVPTKKSQIFSTASDNQPTVTIKVYEGERPLTKDNHLLG
TFDLTGIPPAPRGVPQIEVTFEIDVNGILRVTAEDKGTGNKNKITITNDQNRLTPEEIER
MVNDAEKFAEEDKKLKERIDTRNELESYAYSLKNQIGDKEKLGGKLSSEDKETMEKAVEE
KIEWLESHQDADIEDFKAKKKELEEIVQPIISKLYGSAGPPPTGEEDTAEKDEL
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| BDBM31712 |
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| n/a |
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| Name | BDBM31712 |
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| Synonyms: | HEXACHLOROPHENE | Hexach-lorophene | MLS000028433 | SMR000058356 | cid_3598 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H6Cl6O2 |
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| Mol. Mass. | 406.904 |
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| SMILES | Oc1c(Cl)cc(Cl)c(Cl)c1Cc1c(O)c(Cl)cc(Cl)c1Cl |
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| Structure | 
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