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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Muscarinic acetylcholine receptor M2 | ||
| Ligand | BDBM50522813 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1888527 (CHEMBL4390204) | ||
| Ki | 1.6±n/a nM | ||
| Citation |  Yamashita, Y; Tanaka, KI; Yamakawa, N; Asano, T; Kanda, Y; Takafuji, A; Kawahara, M; Takenaga, M; Fukunishi, Y; Mizushima, T Chemical modification-mediated optimisation of bronchodilatory activity of mepenzolate, a muscarinic receptor antagonist with anti-inflammatory activity. Bioorg Med Chem27:3339-3346 (2019) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Muscarinic acetylcholine receptor M2 | |||
| Name: | Muscarinic acetylcholine receptor M2 | ||
| Synonyms: | ACM2_HUMAN | CHRM2 | Cholinergic, muscarinic M2 | Muscarinic acetylcholine receptor M2 and M4 | Muscarinic acetylcholine receptor M2 and M5 | RecName: Full=Muscarinic acetylcholine receptor M2 | ||
| Type: | GPCR | ||
| Mol. Mass.: | 51730.61 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P08172 | ||
| Residue: | 466 | ||
| Sequence: |
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| BDBM50522813 | |||
| n/a | |||
| Name | BDBM50522813 | ||
| Synonyms: | CHEMBL4539799 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C30H33Br2NO3 | ||
| Mol. Mass. | 615.396 | ||
| SMILES | [Br-].OC(C(=O)OC1C[N+]2(CCCc3ccc(Br)cc3)CCC1CC2)(c1ccccc1)c1ccccc1 |(60.03,-19.13,;50.39,-21.97,;51.73,-22.75,;53.06,-23.51,;53.07,-25.05,;54.39,-22.74,;55.73,-23.51,;57.06,-22.73,;58.38,-23.51,;59.72,-22.74,;61.05,-23.51,;62.38,-22.74,;63.72,-23.52,;63.71,-25.05,;65.04,-25.83,;66.38,-25.06,;67.71,-25.83,;66.37,-23.51,;65.04,-22.75,;58.39,-25.05,;57.06,-25.81,;55.73,-25.05,;57.22,-24.84,;56.87,-23.79,;51.72,-21.21,;53.05,-20.44,;53.05,-18.9,;51.71,-18.13,;50.38,-18.91,;50.39,-20.45,;50.39,-23.52,;49.06,-22.75,;47.73,-23.52,;47.73,-25.06,;49.08,-25.83,;50.4,-25.05,)| | ||
| Structure | 
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