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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Muscarinic acetylcholine receptor M2 | ||
| Ligand | BDBM50522828 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1888527 (CHEMBL4390204) | ||
| Ki | 9.2±n/a nM | ||
| Citation |  Yamashita, Y; Tanaka, KI; Yamakawa, N; Asano, T; Kanda, Y; Takafuji, A; Kawahara, M; Takenaga, M; Fukunishi, Y; Mizushima, T Chemical modification-mediated optimisation of bronchodilatory activity of mepenzolate, a muscarinic receptor antagonist with anti-inflammatory activity. Bioorg Med Chem27:3339-3346 (2019) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Muscarinic acetylcholine receptor M2 | |||
| Name: | Muscarinic acetylcholine receptor M2 | ||
| Synonyms: | ACM2_HUMAN | CHRM2 | Cholinergic, muscarinic M2 | Muscarinic acetylcholine receptor M2 and M4 | Muscarinic acetylcholine receptor M2 and M5 | RecName: Full=Muscarinic acetylcholine receptor M2 | ||
| Type: | GPCR | ||
| Mol. Mass.: | 51730.61 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P08172 | ||
| Residue: | 466 | ||
| Sequence: |
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| BDBM50522828 | |||
| n/a | |||
| Name | BDBM50522828 | ||
| Synonyms: | CHEMBL4470924 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C30H33Br2NO3 | ||
| Mol. Mass. | 615.396 | ||
| SMILES | [Br-].OC(C(=O)OC1C[N+]2(CCCc3cccc(Br)c3)CCC1CC2)(c1ccccc1)c1ccccc1 |(15.57,-3.9,;5.46,-5.76,;6.8,-6.53,;8.14,-7.3,;8.14,-8.84,;9.47,-6.52,;10.8,-7.29,;12.13,-6.51,;13.46,-7.29,;14.79,-6.52,;16.12,-7.29,;17.46,-6.53,;18.79,-7.3,;20.12,-6.53,;21.45,-7.3,;21.45,-8.84,;20.12,-9.61,;20.11,-11.15,;18.78,-8.84,;13.46,-8.83,;12.13,-9.59,;10.8,-8.83,;12.3,-8.63,;11.95,-7.58,;6.8,-4.99,;8.13,-4.22,;8.12,-2.68,;6.79,-1.91,;5.45,-2.7,;5.46,-4.23,;5.47,-7.3,;4.13,-6.53,;2.8,-7.3,;2.81,-8.85,;4.15,-9.61,;5.48,-8.84,)| | ||
| Structure | 
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