| Reaction Details |
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 | Report a problem with these data |
| Target | Gag-Pol polyprotein [489-587] |
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| Ligand | BDBM50078088 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_157707 (CHEMBL763381) |
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| pH | 6.2±n/a |
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| Ki | 0.090000±n/a nM |
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| Comments | extracted |
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| Citation |  Vara Prasad, JV; Boyer, FE; Domagala, JM; Ellsworth, EL; Gajda, C; Hagen, SE; Markoski, LJ; Tait, BD; Lunney, EA; Tummino, PJ; Ferguson, D; Holler, T; Hupe, D; Nouhan, C; Gracheck, SJ; VanderRoest, S; Saunders, J; Iyer, K; Sinz, M; Brodfuehrer, J Nonpeptidic HIV protease inhibitors: 6-alkyl-5,6-dihydropyran-2-ones possessing achiral 3-(4-amino/carboxamide-2-t-butyl,5-methylphenyl thio) moiety: antiviral activities and pharmacokinetic properties. Bioorg Med Chem Lett9:1481-6 (1999) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Gag-Pol polyprotein [489-587] |
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| Name: | Gag-Pol polyprotein [489-587] |
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| Synonyms: | Human immunodeficiency virus type 1 protease | POL_HV1H2 | Pol polyprotein | gag-pol |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 10781.16 |
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| Organism: | Human immunodeficiency virus type 1 |
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| Description: | P04585[489-587] |
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| Residue: | 99 |
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| Sequence: | PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
|
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|
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| BDBM50078088 |
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| n/a |
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| Name | BDBM50078088 |
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| Synonyms: | (S)-3-(2-tert-Butyl-4-hydroxymethyl-5-methyl-phenylsulfanyl)-4-hydroxy-6-[2-(4-hydroxy-phenyl)-ethyl]-6-isopropyl-5,6-dihydro-pyran-2-one | CHEMBL37037 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H36O5S |
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| Mol. Mass. | 484.647 |
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| SMILES | CC(C)[C@]1(CCc2ccc(O)cc2)CC(=O)C(Sc2cc(C)c(CO)cc2C(C)(C)C)C(=O)O1 |
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| Structure | 
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