| Reaction Details |
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 | Report a problem with these data |
| Target | Lysosomal acid glucosylceramidase |
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| Ligand | BDBM50078113 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_71689 (CHEMBL681681) |
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| IC50 | 960.0±n/a nM |
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| Citation |  Ogawa, S; Uetsuki, S; Tezuka, Y; Morikawa, T; Takahashi, A; Sato, K Synthesis and evaluation of glucocerebrosidase inhibitory activity of anhydro deoxyinositols from (+)-epi- and (-)-vibo-quercitols. Bioorg Med Chem Lett9:1493-8 (1999) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Lysosomal acid glucosylceramidase |
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| Name: | Lysosomal acid glucosylceramidase |
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| Synonyms: | Beta-glucocerebrosidase | GBA1_MOUSE | Gba | Gba1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 57628.24 |
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| Organism: | Mus musculus (Mouse) |
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| Description: | P17439 |
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| Residue: | 515 |
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| Sequence: | MAARLIGFFLFQAVSWAYGAQPCIPKSFGYSSVVCVCNASYCDSLDPVTLPALGTFSRYE
STRRGRRMELSVGAIQANRTGTGLLLTLQPEKKFQKVKGFGGAMTDATALNILALSPPTQ
KLLLRSYFSTNGIEYNIIRVPMASCDFSIRVYTYADTPNDFQLSNFSLPEEDTKLKIPLI
HQALKMSSRPISLFASPWTSPTWLKTNGRVNGKGSLKGQPGDIFHQTWANYFVKFLDAYA
KYGLRFWAVTAENEPTAGLFTGYPFQCLGFTPEHQRDFISRDLGPALANSSHDVKLLMLD
DQRLLLPRWAEVVLSDPEAAKYVHGIAVHWYMDFLAPAKATLGETHRLFPNTMLFASEAC
VGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVTGWTDWNLALNPEGGPNWVRNFVDSPI
IVDIPKDAFYKQPMFYHLGHFSKFIPEGSQRVALVASESTDLETVALLRPDGSAVVVVLN
RSSEDVPLTISDPDLGFLETVSPGYSIHTYLWRRQ
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| BDBM50078113 |
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| n/a |
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| Name | BDBM50078113 |
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| Synonyms: | (1S,2R,3S,4R,6R)-7-Oxa-bicyclo[4.1.0]heptane-2,3,4-triol | CHEMBL35833 |
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| Type | Small organic molecule |
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| Emp. Form. | C6H10O4 |
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| Mol. Mass. | 146.1412 |
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| SMILES | O[C@@H]1C[C@H]2O[C@H]2[C@H](O)[C@H]1O |
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| Structure | 
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