Reaction Details | |||
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Target | 3-oxo-5-alpha-steroid 4-dehydrogenase 2 | ||
Ligand | BDBM50043604 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_204742 (CHEMBL805435) | ||
IC50 | 3±n/a nM | ||
Citation | Baston, E; Hartmann, RW N-substituted 4-(5-indolyl)benzoic acids. Synthesis and evaluation of steroid 5alpha-reductase type I and II inhibitory activity. Bioorg Med Chem Lett9:1601-6 (1999) [PubMed] | ||
More Info.: | Get all data from this article, Assay Method | ||
3-oxo-5-alpha-steroid 4-dehydrogenase 2 | |||
Name: | 3-oxo-5-alpha-steroid 4-dehydrogenase 2 | ||
Synonyms: | 3-oxo-5-alpha-steroid 4-dehydrogenase 2 | 5 alpha-SR2 | 5α-Reductase 2 (5α-R2) | S5A2_HUMAN | SR type 2 | SRD5A2 | Steroid 5-alpha-reductase | Steroid 5-alpha-reductase 2 | Type II 5-alpha reductase | ||
Type: | Enzyme | ||
Mol. Mass.: | 28406.59 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P31213 | ||
Residue: | 254 | ||
Sequence: |
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BDBM50043604 | |||
n/a | |||
Name | BDBM50043604 | ||
Synonyms: | (8S,9S,10R,13S,14S,17S)-17-(tert-butylcarbamoyl)-10,13-dimethyl-2,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3-carboxylic acid | 17-tert-Butylcarbamoyl-10,13-dimethyl-2,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3-carboxylic acid | CHEMBL138225 | Epristeride | ||
Type | Small organic molecule | ||
Emp. Form. | C25H37NO3 | ||
Mol. Mass. | 399.5662 | ||
SMILES | CC(C)(C)NC(=O)[C@H]1CC[C@H]2[C@@H]3CC=C4C=C(CC[C@]4(C)[C@H]3CC[C@]12C)C(O)=O |c:15,t:13| | ||
Structure |