| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Xaa-Pro aminopeptidase 1 |
|---|
| Ligand | BDBM50078393 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_35518 (CHEMBL644751) |
|---|
| IC50 | 6800±n/a nM |
|---|
| Citation |  Maggiora, LL; Orawski, AT; Simmons, WH Apstatin analogue inhibitors of aminopeptidase P, a bradykinin-degrading enzyme. J Med Chem42:2394-402 (1999) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Xaa-Pro aminopeptidase 1 |
|---|
| Name: | Xaa-Pro aminopeptidase 1 |
|---|
| Synonyms: | Aminoacylproline aminopeptidase | Cytosolic aminopeptidase P | Soluble aminopeptidase P | X-Pro aminopeptidase 1 | X-prolyl aminopeptidase 1, soluble | XPNPEP1 | XPNPEPL | XPNPEPL1 | XPP1_HUMAN | sAmp |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 69905.93 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_461054 |
|---|
| Residue: | 623 |
|---|
| Sequence: | MPPKVTSELLRQLRQAMRNSEYVTEPIQAYIIPSGDAHQSEYIAPCDCRRAFVSGFDGSA
GTAIITEEHAAMWTDGRYFLQAAKQMDSNWTLMKMGLKDTPTQEDWLVSVLPEGSRVGVD
PLIIPTDYWKKMAKVLRSAGHHLIPVKENLVDKIWTDRPERPCKPLLTLGLDYTGISWKD
KVADLRLKMAERNVMWFVVTALDEIAWLFNLRGSDVEHNPVFFSYAIIGLETIMLFIDGD
RIDAPSVKEHLLLDLGLEAEYRIQVHPYKSILSELKALCADLSPREKVWVSDKASYAVSE
TIPKDHRCCMPYTPICIAKAVKNSAESEGMRRAHIKDAVALCELFNWLEKEVPKGGVTEI
SAADKAEEFRRQQADFVDLSFPTISSTGPNGAIIHYAPVPETNRTLSLDEVYLIDSGAQY
KDGTTDVTRTMHFGTPTAYEKECFTYVLKGHIAVSAAVFPTGTKGHLLDSFARSALWDSG
LDYLHGTGHGVGSFLNVHEGPCGISYKTFSDEPLEAGMIVTDEPGYYEDGAFGIRIENVV
LVVPVKTKYNFNNRGSLTFEPLTLVPIQTKMIDVDSLTDKECDWLNNYHLTCRDVIGKEL
QKQGRQEALEWLIRETQPISKQH
|
|
|
|---|
| BDBM50078393 |
|---|
| n/a |
|---|
| Name | BDBM50078393 |
|---|
| Synonyms: | (S)-1-[(S)-1-((2S,3R)-3-Amino-2-hydroxy-4-phenyl-butyryl)-pyrrolidine-2-carbonyl]-pyrrolidine-2-carboxylic acid {(S)-1-[(S)-1-((R)-1-carbamoyl-2-mercapto-ethylcarbamoyl)-ethylcarbamoyl]-ethyl}-amide | CHEMBL78505 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C29H43N7O7S |
|---|
| Mol. Mass. | 633.759 |
|---|
| SMILES | C[C@H](NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(=O)N[C@@H](CS)C(N)=O |
|---|
| Structure | 
|
|---|
Search and Browse
