| Reaction Details |
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 | Report a problem with these data |
| Target | Xaa-Pro aminopeptidase 2 |
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| Ligand | BDBM50078398 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_35520 (CHEMBL644753) |
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| IC50 | 2600±n/a nM |
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| Citation |  Maggiora, LL; Orawski, AT; Simmons, WH Apstatin analogue inhibitors of aminopeptidase P, a bradykinin-degrading enzyme. J Med Chem42:2394-402 (1999) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Xaa-Pro aminopeptidase 2 |
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| Name: | Xaa-Pro aminopeptidase 2 |
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| Synonyms: | Membrane-bound aminopeptidase P (APP2) | XPNPEP2 | XPP2_HUMAN | Xaa-Pro aminopeptidase 2 |
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| Type: | Enzyme |
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| Mol. Mass.: | 75618.88 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O43895 |
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| Residue: | 674 |
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| Sequence: | MARAHWGCCPWLVLLCACAWGHTKPVDLGGQDVRNCSTNPPYLPVTVVNTTMSLTALRQQ
MQTQNLSAYIIPGTDAHMNEYIGQHDERRAWITGFTGSAGTAVVTMKKAAVWTDSRYWTQ
AERQMDCNWELHKEVGTTPIVTWLLTEIPAGGRVGFDPFLLSIDTWESYDLALQGSNRQL
VSITTNLVDLVWGSERPPVPNQPIYALQEAFTGSTWQEKVSGVRSQMQKHQKVPTAVLLS
ALEETAWLFNLRASDIPYNPFFYSYTLLTDSSIRLFANKSRFSSETLSYLNSSCTGPMCV
QIEDYSQVRDSIQAYSLGDVRIWIGTSYTMYGIYEMIPKEKLVTDTYSPVMMTKAVKNSK
EQALLKASHVRDAVAVIRYLVWLEKNVPKGTVDEFSGAEIVDKFRGEEQFSSGPSFETIS
ASGLNAALAHYSPTKELNRKLSSDEMYLLDSGGQYWDGTTDITRTVHWGTPSAFQKEAYT
RVLIGNIDLSRLIFPAATSGRMVEAFARRALWDAGLNYGHGTGHGIGNFLCVHEWPVGFQ
SNNIAMAKGMFTSIEPGYYKDGEFGIRLEDVALVVEAKTKYPGSYLTFEVVSFVPYDRNL
IDVSLLSPEHLQYLNRYYQTIREKVGPELQRRQLLEEFEWLQQHTEPLAARAPDTASWAS
VLVVSTLAILGWSV
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| BDBM50078398 |
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| n/a |
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| Name | BDBM50078398 |
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| Synonyms: | 2-[(S)-2-((S)-1-Carbamoyl-ethylcarbamoyl)-pyrrolidin-1-yl]-4-phenyl-butyric acid | CHEMBL311925 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H25N3O4 |
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| Mol. Mass. | 347.4088 |
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| SMILES | C[C@H](NC(=O)[C@@H]1CCCN1C(CCc1ccccc1)C(O)=O)C(N)=O |
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| Structure | 
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