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TargetGlycogen synthase kinase-3 beta
LigandBDBM50523830
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1891209 (CHEMBL4393036)
IC50>10000±n/a nM
Citation Lozinskaya, NA; Babkov, DA; Zaryanova, EV; Bezsonova, EN; Efremov, AM; Tsymlyakov, MD; Anikina, LV; Zakharyascheva, OY; Borisov, AV; Perfilova, VN; Tyurenkov, IN; Proskurnina, MV; Spasov, AA Synthesis and biological evaluation of 3-substituted 2-oxindole derivatives as new glycogen synthase kinase 3? inhibitors. Bioorg Med Chem27:1804-1817 (2019) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Glycogen synthase kinase-3 beta
Name:Glycogen synthase kinase-3 beta
Synonyms:GSK-3 beta | GSK-3, beta | GSK3B | GSK3B_HUMAN | Glycogen synthase kinase 3 beta (GSK3B) | Glycogen synthase kinase 3-beta (GSK3B) | Glycogen synthase kinase-3 beta (GSK-3B) | Glycogen synthase kinase-3 beta (GSK3 Beta) | Glycogen synthase kinase-3 beta (GSK3B) | Glycogen synthase kinase-3B (GSK-3B) | Glycogen synthase kinase-3beta (GSK3B) | Serine/threonine-protein kinase GSK3B
Type:Enzyme
Mol. Mass.:46756.38
Organism:Homo sapiens (Human)
Description:P49841
Residue:420
Sequence:
MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTK
VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSG
EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHR
DIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDV
WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHP
WTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALF
NFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50523830
n/a
NameBDBM50523830
Synonyms:CHEMBL4469665
TypeSmall organic molecule
Emp. Form.C14H9BrN2O
Mol. Mass.301.138
SMILESBrc1ccc2NC(=O)C(=Cc3ccncc3)c2c1
Structure
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