| Reaction Details |
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 | Report a problem with these data |
| Target | 72 kDa type IV collagenase |
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| Ligand | BDBM50523895 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1891358 (CHEMBL4393185) |
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| IC50 | 0.048000±n/a nM |
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| Citation |  Lenci, E; Innocenti, R; Di Francescantonio, T; Menchi, G; Bianchini, F; Contini, A; Trabocchi, A Identification of highly potent and selective MMP2 inhibitors addressing the S1' subsite with d-proline-based compounds. Bioorg Med Chem27:1891-1902 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 72 kDa type IV collagenase |
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| Name: | 72 kDa type IV collagenase |
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| Synonyms: | 72 kDa gelatinase | 72 kDa type IV collagenase precursor | CLG4A | Gelatinase A | Gelatinase A (MMP-2) | MMP2 | MMP2_HUMAN | Matrix metalloproteinase-2 | Matrix metalloproteinase-2 (MMP 2) | Matrix metalloproteinase-2 (MMP2) | Matrix metalloproteinases 2 (MMP-2) | TBE-1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 73870.36 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P08253 |
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| Residue: | 660 |
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| Sequence: | MEALMARGALTGPLRALCLLGCLLSHAAAAPSPIIKFPGDVAPKTDKELAVQYLNTFYGC
PKESCNLFVLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNFFPRKPKWD
KNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGD
GYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFPFLFN
GKEYNSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNAEGQPCKFPFRFQGT
SYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFTFLGNKY
ESCTSAGRSDGKMWCATTANYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGAL
MAPIYTYTKNFRLSQDDIKGIQELYGASPDIDLGTGPTPTLGPVTPEICKQDIVFDGIAQ
IRGEIFFFKDRFIWRTVTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEY
WIYSASTLERGYPKPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDP
GFPKLIADAWNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLGC
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| BDBM50523895 |
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| n/a |
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| Name | BDBM50523895 |
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| Synonyms: | CHEMBL4522121 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H29N3O7S |
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| Mol. Mass. | 551.611 |
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| SMILES | ONC(=O)[C@H]1CCCC1S(=O)(=O)c1ccc(NC(=O)c2ccc(CNC(=O)OCc3ccccc3)cc2)cc1 |r| |
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| Structure | 
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