| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tyrosine--tRNA ligase |
|---|
| Ligand | BDBM50524356 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1892855 (CHEMBL4394776) |
|---|
| Ki | 1484±n/a nM |
|---|
| Citation |  Nautiyal, M; De Graef, S; Pang, L; Gadakh, B; Strelkov, SV; Weeks, SD; Van Aerschot, A Comparative analysis of pyrimidine substituted aminoacyl-sulfamoyl nucleosides as potential inhibitors targeting class I aminoacyl-tRNA synthetases. Eur J Med Chem173:154-166 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tyrosine--tRNA ligase |
|---|
| Name: | Tyrosine--tRNA ligase |
|---|
| Synonyms: | 6.1.1.1 | SYY_ECOLI | TyrRS | Tyrosine--tRNA ligase | Tyrosyl-tRNA synthetase | tyrS |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 47522.37 |
|---|
| Organism: | Escherichia coli (strain K12) |
|---|
| Description: | ChEMBL_117817 |
|---|
| Residue: | 424 |
|---|
| Sequence: | MASSNLIKQLQERGLVAQVTDEEALAERLAQGPIALYCGFDPTADSLHLGHLVPLLCLKR
FQQAGHKPVALVGGATGLIGDPSFKAAERKLNTEETVQEWVDKIRKQVAPFLDFDCGENS
AIAANNYDWFGNMNVLTFLRDIGKHFSVNQMINKEAVKQRLNREDQGISFTEFSYNLLQG
YDFACLNKQYGVVLQIGGSDQWGNITSGIDLTRRLHQNQVFGLTVPLITKADGTKFGKTE
GGAVWLDPKKTSPYKFYQFWINTADADVYRFLKFFTFMSIEEINALEEEDKNSGKAPRAQ
YVLAEQVTRLVHGEEGLQAAKRITECLFSGSLSALSEADFEQLAQDGVPMVEMEKGADLM
QALVDSELQPSRGQARKTIASNAITINGEKQSDPEYFFKEEDRLFGRFTLLRRGKKNYCL
ICWK
|
|
|
|---|
| BDBM50524356 |
|---|
| n/a |
|---|
| Name | BDBM50524356 |
|---|
| Synonyms: | CHEMBL4460886 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H23N5O9S |
|---|
| Mol. Mass. | 485.468 |
|---|
| SMILES | N[C@@H](Cc1ccc(O)cc1)C(=O)NS(=O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1ccc(N)nc1=O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
