| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Estrogen receptor |
|---|
| Ligand | BDBM50054811 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_67508 (CHEMBL682292) |
|---|
| IC50 | 500±n/a nM |
|---|
| Citation |  Kraft, KS; Ruenitz, PC; Bartlett, MG Carboxylic acid analogues of tamoxifen: (Z)-2-[p-(1, 2-diphenyl-1-butenyl)phenoxy]-N,N-dimethylethylamine. Estrogen receptor affinity and estrogen antagonist effects in MCF-7 cells. J Med Chem42:3126-33 (1999) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Estrogen receptor |
|---|
| Name: | Estrogen receptor |
|---|
| Synonyms: | ER | ER-alpha | ESR | ESR1 | ESR1_HUMAN | Estradiol receptor | Estrogen receptor | Estrogen receptor (ER alpha) | Estrogen receptor (ER-alpha) | Estrogen receptor alpha (ER alpha) | Estrogen receptor alpha (ER) | NR3A1 | Nuclear receptor subfamily 3 group A member 1 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 66230.44 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P03372 |
|---|
| Residue: | 595 |
|---|
| Sequence: | MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAY
EFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPF
LQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQAC
RLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKR
SKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINW
AKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEG
MVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLD
KITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLL
LEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV
|
|
|
|---|
| BDBM50054811 |
|---|
| n/a |
|---|
| Name | BDBM50054811 |
|---|
| Synonyms: | CHEMBL106773 | {4-[(Z)-1-(4-Hydroxy-phenyl)-2-phenyl-but-1-enyl]-phenoxy}-acetic acid |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H22O4 |
|---|
| Mol. Mass. | 374.4291 |
|---|
| SMILES | CC\C(=C(/c1ccc(O)cc1)c1ccc(OCC(O)=O)cc1)c1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
