| Reaction Details |
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 | Report a problem with these data |
| Target | L-lactate dehydrogenase A chain |
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| Ligand | BDBM50524663 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1894311 (CHEMBL4396232) |
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| EC50 | 4580±n/a nM |
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| Citation |  Zhou, Y; Tao, P; Wang, M; Xu, P; Lu, W; Lei, P; You, Q Development of novel human lactate dehydrogenase A inhibitors: High-throughput screening, synthesis, and biological evaluations. Eur J Med Chem177:105-115 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| L-lactate dehydrogenase A chain |
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| Name: | L-lactate dehydrogenase A chain |
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| Synonyms: | Cell proliferation-inducing gene 19 protein | L-lactate dehydrogenase A | L-lactate dehydrogenase A Chain | LDH muscle subunit | LDH-A | LDH-M | LDHA | LDHA_HUMAN | Lactate dehydrogenase A (LDHA) | Renal carcinoma antigen NY-REN-59 |
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| Type: | Protein |
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| Mol. Mass.: | 36694.85 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00338::PDB Code: 4ajp |
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| Residue: | 332 |
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| Sequence: | MATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKG
EMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFI
IPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGV
HPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYE
VIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGI
SDLVKVTLTSEEEARLKKSADTLWGIQKELQF
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| BDBM50524663 |
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| n/a |
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| Name | BDBM50524663 |
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| Synonyms: | CHEMBL4475383 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H24N2O6 |
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| Mol. Mass. | 388.4144 |
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| SMILES | COc1cc(CNC(=O)c2c3CCCn3c(=O)cc2OC)cc(OC)c1OC |
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| Structure | 
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