| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-lactamase |
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| Ligand | BDBM50079682 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_41360 (CHEMBL656039) |
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| IC50 | 196±n/a nM |
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| Citation |  Buynak, JD; Rao, AS; Doppalapudi, VR; Adam, G; Petersen, PJ; Nidamarthy, SD The synthesis and evaluation of 6-alkylidene-2'beta-substituted penam sulfones as beta-lactamase inhibitors. Bioorg Med Chem Lett9:1997-2002 (1999) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Beta-lactamase |
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| Name: | Beta-lactamase |
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| Synonyms: | BLAC_STAAU | Beta-lactamase TEM | Penicillinase | blaZ |
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| Type: | PROTEIN |
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| Mol. Mass.: | 31367.53 |
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| Organism: | Staphylococcus aureus |
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| Description: | ChEMBL_41052 |
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| Residue: | 281 |
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| Sequence: | MKKLIFLIVIALVLSACNSNSSHAKELNDLEKKYNAHIGVYALDTKSGKEVKFNSDKRFA
YASTSKAINSAILLEQVPYNKLNKKVHINKDDIVAYSPILEKYVGKDITLKALIEASMTY
SDNTANNKIIKEIGGIKKVKQRLKELGDKVTNPVRYEIELNYYSPKSKKDTSTPAAFGKT
LNKLIANGKLSKENKKFLLDLMLNNKSGDTLIKDGVPKDYKVADKSGQAITYASRNDVAF
VYPKGQSEPIVLVIFTNKDNKSDKPNDKLISETAKSVMKEF
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| BDBM50079682 |
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| n/a |
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| Name | BDBM50079682 |
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| Synonyms: | CHEMBL64793 | disodium (2S,3R,5R,6Z)-3-{[(chloroacetyl)oxy]methyl}-3-methyl-6-(2-oxido-2-oxoethylidene)-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4,4-dioxide |
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| Type | Small organic molecule |
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| Emp. Form. | C12H10ClNO9S |
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| Mol. Mass. | 379.728 |
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| SMILES | C[C@]1(COC(=O)CCl)[C@@H](N2C(\C(=C/C([O-])=O)C2=O)S1(=O)=O)C([O-])=O |
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| Structure | 
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