| Reaction Details |
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 | Report a problem with these data |
| Target | Alpha-mannosidase |
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| Ligand | BDBM50525017 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1895273 (CHEMBL4397308) |
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| Ki | 500±n/a nM |
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| Citation |  Rísquez-Cuadro, R; Matsumoto, R; Ortega-Caballero, F; Nanba, E; Higaki, K; García Fernández, JM; Ortiz Mellet, C Pharmacological Chaperones for the Treatment of ?-Mannosidosis. J Med Chem62:5832-5843 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Alpha-mannosidase |
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| Name: | Alpha-mannosidase |
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| Synonyms: | Alpha-mannosidase | Alpha-mannosidase, heavy subunit | Alpha-mannosidase, light subunit | JBM | Jbalpha-man | MANA_CANEN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 108565.93 |
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| Organism: | Canavalia ensiformis |
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| Description: | ChEMBL_109557 |
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| Residue: | 959 |
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| Sequence: | MKYNTGAGTVPEQLNVHLVPHSHDDVGWLKTVDQYYVGSENYIQEACVENVLDSVVMSLQ
RDPNRKFVFGEMAFFHRWWLEQTPETKELKLVKAGQLEFVNGGWCMHDEATTHYIDMIDH
TTLGHRFLQEQFNKIPRAGWQIDPFGHSAVQGYLLGAELGFDSVHFARIDYQDREKRKGE
KSLEVVWRGSKTFGSSAQIFANAFPGHYGPPNGFNFEVRNNFVPLQDDPRLFDTNVEERV
QNFLDAALTQAKLTRTNHLMWTMGDDFQYQYAESWFKQMDKLLHHVNKDGRVNALYSTPS
LYTEAKNAANQTWPLKIDDYFPYADGRNAYWTGFYTSRMLSGYYLATRHSGFFAGKKSTK
YHAFDLADALGIAQHHDAVSGTAKQHTTNDYAKRLALGASKAEAVVSSSLACLTSKQSAD
QCSAPASAFSQCHLFNISYCPPTESSLPDDKSLVVVVYNPLGWSRNEIVRIPVNDANLVV
KDSSGNKLEVQYVEMDDVTANLRSFYVKYWSLFKASVPPLGWSTYFISEATGKGTRNALT
LSQKGETLNIGPGDLKMSFSSLTGQLKRMYNSKTGVDLPIQQNYLWYESSEGDFSDYQAS
GAYLFRPNGQPPPHTVSRSSVTRVTRGPLVDEVHQKFNSWISQVTRLYKDKDHAEIEFTI
GPIPTDDGVGKEVITRMTSTMATNKEFYTDSNGRDFLKRVRDYREDWPLEVTQPVAGNYY
PLNLGLYTKDEKSEFSVLVDRATGGASIKDGEVELMLHRRTLRDDGRGVGEPLDEQVCMN
KEYTCEGLTVRGNYYLSIHKPAGGSRWRRTTGQEIYSPMLLAFTQENMENWKSSHSTKAY
AMDPNYSLPPSVALITLEELDDGLVLLRLAHLYEPSEDAEYSTLTKVELKKLFATQKLEE
LREVSLSANQEKSEMKKMKWSVEGDNEQEPQAVRGGPVSNADFVVELGPMEIRTFLLQF
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| BDBM50525017 |
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| n/a |
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| Name | BDBM50525017 |
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| Synonyms: | CHEMBL4462117 |
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| Type | Small organic molecule |
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| Emp. Form. | C78H135N5O40 |
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| Mol. Mass. | 1782.916 |
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| SMILES | [H][C@]12COC(=O)N1[C@H](NCCCCCCn1cc(COC[C@H]3O[C@@H]4O[C@]5([H])[C@@H](COC)O[C@H](O[C@]6([H])[C@@H](COC)O[C@H](O[C@]7([H])[C@@H](COC)O[C@H](O[C@]8([H])[C@@H](COC)O[C@]([H])(O[C@@H]9[C@@H](COC)O[C@H](O[C@]%10([H])[C@@H](COC)O[C@]([H])(O[C@H]3[C@H](OC)[C@H]4OC)[C@H](OC)[C@H]%10OC)[C@H](OC)[C@H]9OC)[C@H](OC)[C@H]8OC)[C@H](OC)[C@H]7OC)[C@H](OC)[C@H]6OC)[C@H](OC)[C@H]5OC)nn1)[C@@H](O)[C@@H](O)[C@@H]2O |r,@:6| |
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| Structure | 
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