| Reaction Details |
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 | Report a problem with these data |
| Target | Lysosomal alpha-mannosidase |
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| Ligand | BDBM50525020 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1895269 (CHEMBL4397304) |
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| IC50 | 30700±n/a nM |
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| Citation |  Rísquez-Cuadro, R; Matsumoto, R; Ortega-Caballero, F; Nanba, E; Higaki, K; García Fernández, JM; Ortiz Mellet, C Pharmacological Chaperones for the Treatment of ?-Mannosidosis. J Med Chem62:5832-5843 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Lysosomal alpha-mannosidase |
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| Name: | Lysosomal alpha-mannosidase |
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| Synonyms: | LAMAN | MA2B1_HUMAN | MAN2B1 | MANB |
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| Type: | PROTEIN |
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| Mol. Mass.: | 113753.32 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1432452 |
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| Residue: | 1011 |
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| Sequence: | MGAYARASGVCARGCLDSAGPWTMSRALRPPLPPLCFFLLLLAAAGARAGGYETCPTVQP
NMLNVHLLPHTHDDVGWLKTVDQYFYGIKNDIQHAGVQYILDSVISALLADPTRRFIYVE
IAFFSRWWHQQTNATQEVVRDLVRQGRLEFANGGWVMNDEAATHYGAIVDQMTLGLRFLE
DTFGNDGRPRVAWHIDPFGHSREQASLFAQMGFDGFFFGRLDYQDKWVRMQKLEMEQVWR
ASTSLKPPTADLFTGVLPNGYNPPRNLCWDVLCVDQPLVEDPRSPEYNAKELVDYFLNVA
TAQGRYYRTNHTVMTMGSDFQYENANMWFKNLDKLIRLVNAQQAKGSSVHVLYSTPACYL
WELNKANLTWSVKHDDFFPYADGPHQFWTGYFSSRPALKRYERLSYNFLQVCNQLEALVG
LAANVGPYGSGDSAPLNEAMAVLQHHDAVSGTSRQHVANDYARQLAAGWGPCEVLLSNAL
ARLRGFKDHFTFCQQLNISICPLSQTAARFQVIVYNPLGRKVNWMVRLPVSEGVFVVKDP
NGRTVPSDVVIFPSSDSQAHPPELLFSASLPALGFSTYSVAQVPRWKPQARAPQPIPRRS
WSPALTIENEHIRATFDPDTGLLMEIMNMNQQLLLPVRQTFFWYNASIGDNESDQASGAY
IFRPNQQKPLPVSRWAQIHLVKTPLVQEVHQNFSAWCSQVVRLYPGQRHLELEWSVGPIP
VGDTWGKEVISRFDTPLETKGRFYTDSNGREILERRRDYRPTWKLNQTEPVAGNYYPVNT
RIYITDGNMQLTVLTDRSQGGSSLRDGSLELMVHRRLLKDDGRGVSEPLMENGSGAWVRG
RHLVLLDTAQAAAAGHRLLAEQEVLAPQVVLAPGGGAAYNLGAPPRTQFSGLRRDLPPSV
HLLTLASWGPEMVLLRLEHQFAVGEDSGRNLSAPVTLNLRDLFSTFTITRLQETTLVANQ
LREAASRLKWTTNTGPTPHQTPYQLDPANITLEPMEIRTFLASVQWKEVDG
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| BDBM50525020 |
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| n/a |
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| Name | BDBM50525020 |
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| Synonyms: | CHEMBL4518572 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H39N3O7 |
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| Mol. Mass. | 445.5503 |
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| SMILES | [H][C@]12COC(=O)N1[C@H](NCCCCCCCCCNC(=O)OC(C)(C)C)[C@@H](O)[C@@H](O)[C@@H]2O |r,@:6| |
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| Structure | 
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