| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium- and chloride-dependent GABA transporter 3 |
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| Ligand | BDBM50525189 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1896019 (CHEMBL4398054) |
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| IC50 | 1900±n/a nM |
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| Citation |  Giraudo, A; Krall, J; Bavo, F; Nielsen, B; Kongstad, KT; Rolando, B; De Blasio, R; Gloriam, DE; Löffler, R; Thiesen, L; Harpsøe, K; Frydenvang, K; Boschi, D; Wellendorph, P; Lolli, ML; Jensen, AA; Frølund, B Five-Membered N-Heterocyclic Scaffolds as Novel Amino Bioisosteres at ?-Aminobutyric Acid (GABA) Type A Receptors and GABA Transporters. J Med Chem62:5797-5809 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium- and chloride-dependent GABA transporter 3 |
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| Name: | Sodium- and chloride-dependent GABA transporter 3 |
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| Synonyms: | GABA transporter 3 | GABT3 | GAT-3 | GAT3 | S6A11_HUMAN | SLC6A11 | Solute carrier family 6 member 11 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 70607.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1454198 |
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| Residue: | 632 |
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| Sequence: | MTAEKALPLGNGKAAEEARESEAPGGGCSSGGAAPARHPRVKRDKAVHERGHWNNKVEFV
LSVAGEIIGLGNVWRFPYLCYKNGGGAFLIPYVVFFICCGIPVFFLETALGQFTSEGGIT
CWRKVCPLFEGIGYATQVIEAHLNVYYIIILAWAIFYLSNCFTTELPWATCGHEWNTENC
VEFQKLNVSNYSHVSLQNATSPVMEFWEHRVLAISDGIEHIGNLRWELALCLLAAWTICY
FCIWKGTKSTGKVVYVTATFPYIMLLILLIRGVTLPGASEGIKFYLYPDLSRLSDPQVWV
DAGTQIFFSYAICLGCLTALGSYNNYNNNCYRDCIMLCCLNSGTSFVAGFAIFSVLGFMA
YEQGVPIAEVAESGPGLAFIAYPKAVTMMPLSPLWATLFFMMLIFLGLDSQFVCVESLVT
AVVDMYPKVFRRGYRRELLILALSVISYFLGLVMLTEGGMYIFQLFDSYAASGMCLLFVA
IFECICIGWVYGSNRFYDNIEDMIGYRPPSLIKWCWMIMTPGICAGIFIFFLIKYKPLKY
NNIYTYPAWGYGIGWLMALSSMLCIPLWICITVWKTEGTLPEKLQKLTTPSTDLKMRGKL
GVSPRMVTVNDCDAKLKSDGTIAAITEKETHF
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| BDBM50525189 |
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| n/a |
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| Name | BDBM50525189 |
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| Synonyms: | CHEMBL4458674 |
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| Type | Small organic molecule |
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| Emp. Form. | C5H8N2O2 |
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| Mol. Mass. | 128.1292 |
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| SMILES | OC(=O)CC1CNC=N1 |c:7| |
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| Structure | 
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