| Reaction Details |
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 | Report a problem with these data |
| Target | Phosphatidylcholine:ceramide cholinephosphotransferase 1 |
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| Ligand | BDBM50182487 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1897472 (CHEMBL4399507) |
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| IC50 | 2000±n/a nM |
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| Citation |  Othman, MA; Yuyama, K; Murai, Y; Igarashi, Y; Mikami, D; Sivasothy, Y; Awang, K; Monde, K Malabaricone C as Natural Sphingomyelin Synthase Inhibitor against Diet-Induced Obesity and Its Lipid Metabolism in Mice. ACS Med Chem Lett10:1154-1158 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Phosphatidylcholine:ceramide cholinephosphotransferase 1 |
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| Name: | Phosphatidylcholine:ceramide cholinephosphotransferase 1 |
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| Synonyms: | MOB | Medulla oblongata-derived protein | Protein Mob | SGMS1 | SMS1 | SMS1_HUMAN | Sphingomyelin synthase 1 | TMEM23 | Transmembrane protein 23 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 48630.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_109868 |
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| Residue: | 413 |
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| Sequence: | MKEVVYWSPKKVADWLLENAMPEYCEPLEHFTGQDLINLTQEDFKKPPLCRVSSDNGQRL
LDMIETLKMEHHLEAHKNGHANGHLNIGVDIPTPDGSFSIKIKPNGMPNGYRKEMIKIPM
PELERSQYPMEWGKTFLAFLYALSCFVLTTVMISVVHERVPPKEVQPPLPDTFFDHFNRV
QWAFSICEINGMILVGLWLIQWLLLKYKSIISRRFFCIVGTLYLYRCITMYVTTLPVPGM
HFNCSPKLFGDWEAQLRRIMKLIAGGGLSITGSHNMCGDYLYSGHTVMLTLTYLFIKEYS
PRRLWWYHWICWLLSVVGIFCILLAHDHYTVDVVVAYYITTRLFWWYHTMANQQVLKEAS
QMNLLARVWWYRPFQYFEKNVQGIVPRSYHWPFPWPVVHLSRQVKYSRLVNDT
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| BDBM50182487 |
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| n/a |
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| Name | BDBM50182487 |
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| Synonyms: | Malabaricone A |
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| Type | Small organic molecule |
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| Emp. Form. | C21H26O3 |
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| Mol. Mass. | 326.4293 |
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| SMILES | Oc1cccc(O)c1C(=O)CCCCCCCCc1ccccc1 |
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| Structure | 
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