Reaction Details |
| Report a problem with these data |
Target | 17-beta-hydroxysteroid dehydrogenase type 2 |
---|
Ligand | BDBM50126982 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1898526 (CHEMBL4400641) |
---|
IC50 | 111±n/a nM |
---|
Citation | Abdelsamie, AS; Herath, S; Biskupek, Y; Börger, C; Siebenbürger, L; Salah, M; Scheuer, C; Marchais-Oberwinkler, S; Frotscher, M; Pohlemann, T; Menger, MD; Hartmann, RW; Laschke, MW; van Koppen, CJ Targeted Endocrine Therapy: Design, Synthesis, and Proof-of-Principle of 17?-Hydroxysteroid Dehydrogenase Type 2 Inhibitors in Bone Fracture Healing. J Med Chem62:1362-1372 (2019) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
17-beta-hydroxysteroid dehydrogenase type 2 |
---|
Name: | 17-beta-hydroxysteroid dehydrogenase type 2 |
Synonyms: | 17-beta-Hydroxysteroid Dehydrogenase 2 (17-beta-HSD2) | 20 alpha-hydroxysteroid dehydrogenase | 20-alpha-HSD | DHB2_HUMAN | EDH17B2 | Estradiol 17-beta-dehydrogenase 2 | Estradiol 17-beta-dehydrogenase 2 (17beta-HSD2) | HSD17B2 | Microsomal 17-beta-hydroxysteroid dehydrogenas | SDR9C2 | Testosterone 17-beta-dehydrogenase |
Type: | Oxidoreductase; single-pass type II membrane protein |
Mol. Mass.: | 42795.29 |
Organism: | Homo sapiens (Human) |
Description: | Enzyme was partially purified from human placenta. |
Residue: | 387 |
Sequence: | MSTFFSDTAWICLAVPTVLCGTVFCKYKKSSGQLWSWMVCLAGLCAVCLLILSPFWGLIL
FSVSCFLMYTYLSGQELLPVDQKAVLVTGGDCGLGHALCKYLDELGFTVFAGVLNENGPG
AEELRRTCSPRLSVLQMDITKPVQIKDAYSKVAAMLQDRGLWAVINNAGVLGFPTDGELL
LMTDYKQCMAVNFFGTVEVTKTFLPLLRKSKGRLVNVSSMGGGAPMERLASYGSSKAAVT
MFSSVMRLELSKWGIKVASIQPGGFLTNIAGTSDKWEKLEKDILDHLPAEVQEDYGQDYI
LAQRNFLLLINSLASKDFSPVLRDIQHAILAKSPFAYYTPGKGAYLWICLAHYLPIGIYD
YFAKRHFGQDKPMPRALRMPNYKKKAT
|
|
|
BDBM50126982 |
---|
n/a |
---|
Name | BDBM50126982 |
Synonyms: | CHEMBL3629438 |
Type | Small organic molecule |
Emp. Form. | C23H17NO4S2 |
Mol. Mass. | 435.515 |
SMILES | Oc1cccc(c1)C(=O)c1ccc(s1)-c1cccc(NS(=O)(=O)c2ccccc2)c1 |
Structure |
|