| Reaction Details |
|---|
 | Report a problem with these data |
| Target | 17-beta-hydroxysteroid dehydrogenase type 1 |
|---|
| Ligand | BDBM50525962 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1898527 (CHEMBL4400642) |
|---|
| IC50 | 0.800000±n/a nM |
|---|
| Citation |  Abdelsamie, AS; Herath, S; Biskupek, Y; Börger, C; Siebenbürger, L; Salah, M; Scheuer, C; Marchais-Oberwinkler, S; Frotscher, M; Pohlemann, T; Menger, MD; Hartmann, RW; Laschke, MW; van Koppen, CJ Targeted Endocrine Therapy: Design, Synthesis, and Proof-of-Principle of 17?-Hydroxysteroid Dehydrogenase Type 2 Inhibitors in Bone Fracture Healing. J Med Chem62:1362-1372 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| 17-beta-hydroxysteroid dehydrogenase type 1 |
|---|
| Name: | 17-beta-hydroxysteroid dehydrogenase type 1 |
|---|
| Synonyms: | 17-beta-HSD 1 | 17-beta-Hydroxysteroid Dehydrogenase 1 (17-beta-HSD1) | 17-beta-hydroxysteroid dehydrogenase type 1 | 20 alpha-hydroxysteroid dehydrogenase | 20-alpha-HSD | DHB1_HUMAN | E17KSR | E2DH | EDH17B1 | EDH17B2 | EDHB17 | Estradiol 17-beta-dehydrogenase 1 | Estradiol 17-beta-dehydrogenase 1 (17beta-HSD1) | HSD17B1 | Placental 17-beta-hydroxysteroid dehydrogenase | SDR28C1 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 34945.13 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P14061 |
|---|
| Residue: | 328 |
|---|
| Sequence: | MARTVVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSL
ETLQLDVRDSKSVAAARERVTEGRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVGTV
RMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFGVH
LSLIECGPVHTAFMEKVLGSPEEVLDRTDIHTFHRFYQYLAHSKQVFREAAQNPEEVAEV
FLTALRAPKPTLRYFTTERFLPLLRMRLDDPSGSNYVTAMHREVFGDVPAKAEAGAEAGG
GAGPGAEDEAGRGAVGDPELGDPPAAPQ
|
|
|
|---|
| BDBM50525962 |
|---|
| n/a |
|---|
| Name | BDBM50525962 |
|---|
| Synonyms: | CHEMBL4464314 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H13ClF3NO4S2 |
|---|
| Mol. Mass. | 523.932 |
|---|
| SMILES | Oc1c(F)c(F)cc(C(=O)c2ccc(s2)-c2cccc(NS(=O)(=O)c3cccc(Cl)c3)c2)c1F |
|---|
| Structure | 
|
|---|
Search and Browse
