| Reaction Details |
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 | Report a problem with these data |
| Target | Lysophosphatidylserine lipase ABHD12 |
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| Ligand | BDBM50526068 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1899079 (CHEMBL4401194) |
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| IC50 | 90000±n/a nM |
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| Citation |  Ogasawara, D; Ichu, TA; Jing, H; Hulce, JJ; Reed, A; Ulanovskaya, OA; Cravatt, BF Discovery and Optimization of Selective and in Vivo Active Inhibitors of the Lysophosphatidylserine Lipase ?/?-Hydrolase Domain-Containing 12 (ABHD12). J Med Chem62:1643-1656 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Lysophosphatidylserine lipase ABHD12 |
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| Name: | Lysophosphatidylserine lipase ABHD12 |
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| Synonyms: | ABD12_MOUSE | Abhd12 | Monoacylglycerol lipase ABHD12 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 45284.87 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_643596 |
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| Residue: | 398 |
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| Sequence: | MRKRTEPVTLEHERCAASGSSSSGSAAAALDADCSLKQNLRLAGKGTAEPHSASDAGMKR
ALGRRKSLWFRLRKILLCVLGFYIAIPFLVKLCPGIQAKLIFLNFVRVPYFIDLKKPQDQ
GLNHTCNYYLQPEDDVTIGVWHTIPSVWWKNAQGKDQMWYEDALASNHAIILYLHGNAGT
RGGDHRVELYKVLSSLGYHVVTFDYRGWGDSVGTPSERGMTYDALHVFDWIKARSGDNPV
YIWGHSLGTGVATNLVRRLCERETPPDALILESPFTNIREEAKSHPFSVIYRYFPGFDWF
FLDPITSSGIKFANDENMKHISCPLLILHAEDDPVVPFHLGRKLYNIAAPSRSFRDFKVQ
FIPFHSDLGYRHKYIYKSPELPRILREFLGKSEPERQH
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| BDBM50526068 |
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| n/a |
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| Name | BDBM50526068 |
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| Synonyms: | CHEMBL4529112 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H20Cl2F3N5O2S |
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| Mol. Mass. | 558.403 |
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| SMILES | FC(F)(F)Oc1ccc(Oc2ccnc(N3CCCC(C3)NC(=S)Nc3cccnc3)c2Cl)c(Cl)c1 |
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| Structure | 
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