| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Retinoic acid receptor beta |
|---|
| Ligand | BDBM50526314 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1899798 (CHEMBL4401913) |
|---|
| EC50 | 1.9±n/a nM |
|---|
| Citation |  Goncalves, MB; Clarke, E; Jarvis, CI; Barret Kalindjian, S; Pitcher, T; Grist, J; Hobbs, C; Carlstedt, T; Jack, J; Brown, JT; Mills, M; Mumford, P; Borthwick, AD; Corcoran, JPT Discovery and lead optimisation of a potent, selective and orally bioavailable RAR? agonist for the potential treatment of nerve injury. Bioorg Med Chem Lett29:995-1000 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Retinoic acid receptor beta |
|---|
| Name: | Retinoic acid receptor beta |
|---|
| Synonyms: | Nr1b2 | Nuclear receptor subfamily 1 group B member 2 | RAR-beta | RARB_MOUSE | Rarb |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 53344.93 |
|---|
| Organism: | Mus musculus |
|---|
| Description: | ChEMBL_195641 |
|---|
| Residue: | 482 |
|---|
| Sequence: | MSTSSHACPVPAVRGHMTHYPAAPYPLLFPPVIRGLSLPPLHGLHGHPPPSGCSTPSPAS
VGQACQRTTGGSQFAASTKWTPSLNAAIETQSTSSEELVPSPPSPLPPPRVYKPCFVCQD
KSSGYHYGVSACEGCKGFFRRSIQKNMIYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGM
SKESVRNDRNKKKKEPSKQECTESYEMTAELDDLTEKIRKAHQETFPSLCQLGKYTTNSS
ADHRVRLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILILRI
CTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFTFANQLLPLEMDDTETGLLSAIC
LICGDRQDLEEPTKVDKLQEPLLEALKIYIRKRRPSKPHMFPKILMKITDLRSISAKGAE
RVITLKMEIPGSMPPLIQEMLENSEGHEPLTPSSSGNIAEHSPSVSPSSVENSGVSQSPL
LQ
|
|
|
|---|
| BDBM50526314 |
|---|
| n/a |
|---|
| Name | BDBM50526314 |
|---|
| Synonyms: | CHEMBL4459692 | US10752616, Code No. BHBA-001 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H14N2O4 |
|---|
| Mol. Mass. | 334.3255 |
|---|
| SMILES | Cc1ccc(C)c2oc(cc12)-c1nc(no1)-c1ccc(cc1)C(O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
