| Reaction Details |
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 | Report a problem with these data |
| Target | Serine protease 1 |
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| Ligand | BDBM50081501 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_210648 |
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| Ki | >2900±n/a nM |
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| Citation |  Becker, MR; Ewing, WR; Davis, RS; Pauls, HW; Ly, C; Li, A; Mason, HJ; Choi-Sledeski, YM; Spada, AP; Chu, V; Brown, KD; Colussi, DJ; Leadley, RJ; Bentley, R; Bostwick, J; Kasiewski, C; Morgan, S Synthesis, SAR and in vivo activity of novel thienopyridine sulfonamide pyrrolidinones as factor Xa inhibitors. Bioorg Med Chem Lett9:2753-8 (1999) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine protease 1 |
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| Name: | Serine protease 1 |
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| Synonyms: | Alpha-trypsin chain 1 | Alpha-trypsin chain 2 | Beta-trypsin | Cationic trypsinogen | PRSS1 | Serine protease 1 | TRP1 | TRY1 | TRY1_HUMAN | TRYP1 | Thrombin & trypsin | Trypsin | Trypsin I | Trypsin-1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 26557.80 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P07477 |
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| Residue: | 247 |
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| Sequence: | MNPLLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLNSGYHFCGGSLINEQWVVS
AGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVIN
ARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKIT
SNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGDGCAQKNKPGVYTKVYNYVKWIK
NTIAANS
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| BDBM50081501 |
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| n/a |
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| Name | BDBM50081501 |
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| Synonyms: | 3-[(S)-3-(Isoquinoline-6-sulfonylamino)-2-oxo-pyrrolidin-1-ylmethyl]-benzamidine | CHEMBL92345 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H21N5O3S |
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| Mol. Mass. | 423.488 |
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| SMILES | NC(=N)c1cccc(CN2CC[C@H](NS(=O)(=O)c3ccc4cnccc4c3)C2=O)c1 |
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| Structure | 
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