| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Coagulation factor X |
|---|
| Ligand | BDBM50081516 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_69683 |
|---|
| Ki | 420±n/a nM |
|---|
| Citation |  Becker, MR; Ewing, WR; Davis, RS; Pauls, HW; Ly, C; Li, A; Mason, HJ; Choi-Sledeski, YM; Spada, AP; Chu, V; Brown, KD; Colussi, DJ; Leadley, RJ; Bentley, R; Bostwick, J; Kasiewski, C; Morgan, S Synthesis, SAR and in vivo activity of novel thienopyridine sulfonamide pyrrolidinones as factor Xa inhibitors. Bioorg Med Chem Lett9:2753-8 (1999) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Coagulation factor X |
|---|
| Name: | Coagulation factor X |
|---|
| Synonyms: | Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 54726.60 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 488 |
|---|
| Sequence: | MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
|
|
|
|---|
| BDBM50081516 |
|---|
| n/a |
|---|
| Name | BDBM50081516 |
|---|
| Synonyms: | 3-[(S)-2-Oxo-3-(quinoline-7-sulfonylamino)-pyrrolidin-1-ylmethyl]-benzamidine | CHEMBL93741 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H21N5O3S |
|---|
| Mol. Mass. | 423.488 |
|---|
| SMILES | NC(=N)c1cccc(CN2CC[C@H](NS(=O)(=O)c3ccc4cccnc4c3)C2=O)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
