| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Polyphenol oxidase 2 |
|---|
| Ligand | BDBM50061554 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1900392 (CHEMBL4402614) |
|---|
| IC50 | 3200±n/a nM |
|---|
| Citation |  Kim, JY; Kim, JY; Jenis, J; Li, ZP; Ban, YJ; Baiseitova, A; Park, KH Tyrosinase inhibitory study of flavonolignans from the seeds of Silybum marianum (Milk thistle). Bioorg Med Chem27:2499-2507 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Polyphenol oxidase 2 |
|---|
| Name: | Polyphenol oxidase 2 |
|---|
| Synonyms: | Monophenol monooxygenase | Monophenol oxidase | PPO2 | PPO2_AGABI | Tyrosinase |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 63923.66 |
|---|
| Organism: | Agaricus bisporus (Common mushroom) |
|---|
| Description: | O42713 |
|---|
| Residue: | 556 |
|---|
| Sequence: | MSLIATVGPTGGVKNRLNIVDFVKNEKFFTLYVRSLELLQAKEQHDYSSFFQLAGIHGLP
FTEWAKERPSMNLYKAGYCTHGQVLFPTWHRTYLSVLEQILQGAAIEVAKKFTSNQTDWV
QAAQDLRQPYWDWGFELMPPDEVIKNEEVNITNYDGKKISVKNPILRYHFHPIDPSFKPY
GDFATWRTTVRNPDRNRREDIPGLIKKMRLEEGQIREKTYNMLKFNDAWERFSNHGISDD
QHANSLESVHDDIHVMVGYGKIEGHMDHPFFAAFDPIFWLHHTNVDRLLSLWKAINPDVW
VTSGRNRDGTMGIAPNAQINSETPLEPFYQSGDKVWTSASLADTARLGYSYPDFDKLVGG
TKELIRDAIDDLIDERYGSKPSSGARNTAFDLLADFKGITKEHKEDLKMYDWTIHVAFKK
FELKESFSLLFYFASDGGDYDQENCFVGSINAFRGTAPETCANCQDNENLIQEGFIHLNH
YLARDLESFEPQDVHKFLKEKGLSYKLYSRGDKPLTSLSVKIEGRPLHLPPGEHRPKYDH
TQARVVFDDVAVHVIN
|
|
|
|---|
| BDBM50061554 |
|---|
| n/a |
|---|
| Name | BDBM50061554 |
|---|
| Synonyms: | (+)-Silychristin | (2R,3R)-3,5,7-Trihydroxy-2-[(2R,3S)-7-hydroxy-2-(4-hydroxy-3-methoxy-phenyl)-3-hydroxymethyl-2,3-dihydro-benzofuran-5-yl]-chroman-4-one | CHEMBL130493 | SILYCHRISTIN |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H22O10 |
|---|
| Mol. Mass. | 482.4362 |
|---|
| SMILES | COc1cc(ccc1O)[C@@H]1Oc2c(cc(cc2O)[C@H]2Oc3cc(O)cc(O)c3C(O)C2=O)[C@H]1CO |r| |
|---|
| Structure | 
|
|---|
Search and Browse
