| Reaction Details |
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 | Report a problem with these data |
| Target | Lysyl oxidase homolog 3 |
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| Ligand | BDBM50232678 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1901015 (CHEMBL4403237) |
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| IC50 | 310±n/a nM |
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| Citation |  Smithen, DA; Leung, LMH; Challinor, M; Lawrence, R; Tang, H; Niculescu-Duvaz, D; Pearce, SP; Mcleary, R; Lopes, F; Aljarah, M; Brown, M; Johnson, L; Thomson, G; Marais, R; Springer, C 2-Aminomethylene-5-sulfonylthiazole Inhibitors of Lysyl Oxidase (LOX) and LOXL2 Show Significant Efficacy in Delaying Tumor Growth. J Med Chem63:2308-2324 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Lysyl oxidase homolog 3 |
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| Name: | Lysyl oxidase homolog 3 |
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| Synonyms: | 1.4.3.- | 1.4.3.13 | LOXL | LOXL3 | LOXL3_HUMAN | Lysyl oxidase homolog 3 | Lysyl oxidase-like protein 3 | Synonyms=LOXL |
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| Type: | PROTEIN |
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| Mol. Mass.: | 83173.13 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_117594 |
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| Residue: | 753 |
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| Sequence: | MRPVSVWQWSPWGLLLCLLCSSCLGSPSPSTGPEKKAGSQGLRFRLAGFPRKPYEGRVEI
QRAGEWGTICDDDFTLQAAHILCRELGFTEATGWTHSAKYGPGTGRIWLDNLSCSGTEQS
VTECASRGWGNSDCTHDEDAGVICKDQRLPGFSDSNVIEVEHHLQVEEVRIRPAVGWGRR
PLPVTEGLVEVRLPDGWSQVCDKGWSAHNSHVVCGMLGFPSEKRVNAAFYRLLAQRQQHS
FGLHGVACVGTEAHLSLCSLEFYRANDTARCPGGGPAVVSCVPGPVYAASSGQKKQQQSK
PQGEARVRLKGGAHPGEGRVEVLKASTWGTVCDRKWDLHAASVVCRELGFGSAREALSGA
RMGQGMGAIHLSEVRCSGQELSLWKCPHKNITAEDCSHSQDAGVRCNLPYTGAETRIRLS
GGRSQHEGRVEVQIGGPGPLRWGLICGDDWGTLEAMVACRQLGLGYANHGLQETWYWDSG
NITEVVMSGVRCTGTELSLDQCAHHGTHITCKRTGTRFTAGVICSETASDLLLHSALVQE
TAYIEDRPLHMLYCAAEENCLASSARSANWPYGHRRLLRFSSQIHNLGRADFRPKAGRHS
WVWHECHGHYHSMDIFTHYDILTPNGTKVAEGHKASFCLEDTECQEDVSKRYECANFGEQ
GITVGCWDLYRHDIDCQWIDITDVKPGNYILQVVINPNFEVAESDFTNNAMKCNCKYDGH
RIWVHNCHIGDAFSEEANRRFERYPGQTSNQII
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| BDBM50232678 |
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| n/a |
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| Name | BDBM50232678 |
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| Synonyms: | CHEBI:27413 | CHEMBL1618272 | US10717734, Compound BAPN | US11098045, Compound BAPN |
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| Type | Small organic molecule |
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| Emp. Form. | C3H6N2 |
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| Mol. Mass. | 70.0931 |
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| SMILES | NCCC#N |
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| Structure | 
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