Ki Summary

Reaction Details

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Target

Gamma-aminobutyric acid receptor subunit alpha-2

Ligand

BDBM50418481

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1901495 (CHEMBL4403717)

0.309030±n/a nM

Citation

Maramai, S; Benchekroun, M; Ward, SE; Atack, JR Subtype Selective ?-Aminobutyric Acid Type A Receptor (GABA J Med Chem63:3425-3446 (2020) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Gamma-aminobutyric acid receptor subunit alpha-2

Name:

Gamma-aminobutyric acid receptor subunit alpha-2

Synonyms:

GABA receptor alpha-2 subunit | GABRA2 | GBRA2_HUMAN | Gamma-aminobutyric acid receptor subunit alpha-2 (GABRA2)

Type:

Protein

Mol. Mass.:

51338.78

Organism:

Homo sapiens (Human)

Description:

P47869

Residue:

451

Sequence:

MKTKLNIYNMQFLLFVFLVWDPARLVLANIQEDEAKNNITIFTRILDRLLDGYDNRLRPG
LGDSITEVFTNIYVTSFGPVSDTDMEYTIDVFFRQKWKDERLKFKGPMNILRLNNLMASK
IWTPDTFFHNGKKSVAHNMTMPNKLLRIQDDGTLLYTMRLTVQAECPMHLEDFPMDAHSC
PLKFGSYAYTTSEVTYIWTYNASDSVQVAPDGSRLNQYDLLGQSIGKETIKSSTGEYTVM
TAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISA
RNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWAWDGKSVVNDKKKEKASV
MIQNNAYAVAVANYAPNLSKDPVLSTISKSATTPEPNKKPENKPAEAKKTFNSVSKIDRM
SRIVFPVLFGTFNLVYWATYLNREPVLGVSP

BDBM50418481

n/a

Name

BDBM50418481

Synonyms:

CHEMBL1783282

Type

Small organic molecule

Emp. Form.

C19H19FN4O2

Mol. Mass.

354.3782

SMILES

CCCNC(=O)c1nnc2c(cccc2c1N)-c1c(F)cccc1OC |(3.52,-21.84,;2.19,-22.61,;.85,-21.84,;-.48,-22.61,;-1.81,-21.84,;-1.81,-20.3,;-3.15,-22.61,;-3.16,-24.17,;-4.5,-24.95,;-5.84,-24.18,;-7.18,-24.95,;-8.51,-24.18,;-8.51,-22.63,;-7.18,-21.86,;-5.85,-22.63,;-4.51,-21.84,;-4.52,-20.3,;-7.18,-26.49,;-5.85,-27.25,;-4.52,-26.47,;-5.85,-28.78,;-7.19,-29.56,;-8.52,-28.78,;-8.52,-27.25,;-9.85,-26.47,;-9.84,-24.93,)|

Structure