| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Decaprenylphosphoryl-beta-D-ribose oxidase |
|---|
| Ligand | BDBM50528136 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1904470 (CHEMBL4406692) |
|---|
| IC50 | 200±n/a nM |
|---|
| Citation |  Balabon, O; Pitta, E; Rogacki, MK; Meiler, E; Casanueva, R; Guijarro, L; Huss, S; Lopez-Roman, EM; Santos-Villarejo, Á; Augustyns, K; Ballell, L; Aguirre, DB; Bates, RH; Cunningham, F; Cacho, M; Van der Veken, P Optimization of Hydantoins as Potent Antimycobacterial Decaprenylphosphoryl-?-d-Ribose Oxidase (DprE1) Inhibitors. J Med Chem63:5367-5386 (2020) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Decaprenylphosphoryl-beta-D-ribose oxidase |
|---|
| Name: | Decaprenylphosphoryl-beta-D-ribose oxidase |
|---|
| Synonyms: | DPRE1_MYCTU | Decaprenylphospho-beta-D-ribofuranose 2-dehydrogenase | Decaprenylphosphoryl-beta-D-ribose 2-epimerase flavoprotein subunit | Decaprenylphosphoryl-beta-D-ribose oxidase | FAD-dependent decaprenylphosphoryl-beta-D-ribofuranose 2-oxidase | dprE1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 50167.60 |
|---|
| Organism: | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
|---|
| Description: | ChEMBL_116793 |
|---|
| Residue: | 461 |
|---|
| Sequence: | MLSVGATTTATRLTGWGRTAPSVANVLRTPDAEMIVKAVARVAESGGGRGAIARGLGRSY
GDNAQNGGGLVIDMTPLNTIHSIDADTKLVDIDAGVNLDQLMKAALPFGLWVPVLPGTRQ
VTVGGAIACDIHGKNHHSAGSFGNHVRSMDLLTADGEIRHLTPTGEDAELFWATVGGNGL
TGIIMRATIEMTPTSTAYFIADGDVTASLDETIALHSDGSEARYTYSSAWFDAISAPPKL
GRAAVSRGRLATVEQLPAKLRSEPLKFDAPQLLTLPDVFPNGLANKYTFGPIGELWYRKS
GTYRGKVQNLTQFYHPLDMFGEWNRAYGPAGFLQYQFVIPTEAVDEFKKIIGVIQASGHY
SFLNVFKLFGPRNQAPLSFPIPGWNICVDFPIKDGLGKFVSELDRRVLEFGGRLYTAKDS
RTTAETFHAMYPRVDEWISVRRKVDPLRVFASDMARRLELL
|
|
|
|---|
| BDBM50528136 |
|---|
| n/a |
|---|
| Name | BDBM50528136 |
|---|
| Synonyms: | CHEMBL4453781 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H16N4O5S2 |
|---|
| Mol. Mass. | 444.484 |
|---|
| SMILES | CC1(NC(=O)N(CC(=O)c2nc3ccccc3s2)C1=O)c1ccc(cc1)S(N)(=O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
