Reaction Details |
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Target | Alpha-1B adrenergic receptor |
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Ligand | BDBM50082811 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_34458 (CHEMBL651990) |
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Ki | 30±n/a nM |
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Citation | Murali Dhar, TG; Nagarathnam, D; Marzabadi, MR; Lagu, B; Wong, WC; Chiu, G; Tyagarajan, S; Miao, SW; Zhang, F; Sun, W; Tian, D; Shen, Q; Zhang, J; Wetzel, JM; Forray, C; Chang, RS; Broten, TP; Schorn, TW; Chen, TB; O'Malley, S; Ransom, R; Schneck, K; Bendesky, R; Harrell, CM; Vyas, KP Design and synthesis of novel alpha(1)(a) adrenoceptor-selective antagonists. 2. Approaches to eliminate opioid agonist metabolites via modification of linker and 4-methoxycarbonyl-4-phenylpiperidine moiety. J Med Chem42:4778-93 (1999) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Alpha-1B adrenergic receptor |
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Name: | Alpha-1B adrenergic receptor |
Synonyms: | ADA1B_HUMAN | ADRA1B | Adrenergic alpha1B | Adrenergic receptor | Adrenergic receptor alpha | Alpha 1B-adrenoceptor | Alpha 1B-adrenoreceptor | Alpha-1B adrenergic receptor |
Type: | Enzyme |
Mol. Mass.: | 56862.13 |
Organism: | Homo sapiens (Human) |
Description: | P35368 |
Residue: | 520 |
Sequence: | MNPDLDTGHNTSAPAHWGELKNANFTGPNQTSSNSTLPQLDITRAISVGLVLGAFILFAI
VGNILVILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAALEVLGYWVLGRIFCDI
WAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGP
LLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAG
VMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVV
GMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFV
RILGCQCRGRGRRRRRRRRRLGGCAYTYRPWTRGGSLERSQSRKDSLDDSGSCLSGSQRT
LPSASPSPGYLGRGAPPPVELCAFPEWKAPGALLSLPAPEPPGRRGRHDSGPLFTFKLLT
EPESPGTDGGASNGGCEAAADVANGQPGFKSNMPLAPGQF
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BDBM50082811 |
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n/a |
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Name | BDBM50082811 |
Synonyms: | 3-{3-[4-Cyano-4-(4-fluoro-phenyl)-piperidin-1-yl]-propylcarbamoyl}-4-(3,4-difluoro-phenyl)-6-methoxymethyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid methyl ester | CHEMBL144933 |
Type | Small organic molecule |
Emp. Form. | C30H32F3N5O5 |
Mol. Mass. | 599.6008 |
SMILES | COCC1=C(C(N(C(=O)NCCCN2CCC(CC2)(C#N)c2ccc(F)cc2)C(=O)N1)c1ccc(F)c(F)c1)C(=O)OC |t:3| |
Structure |
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