Reaction Details |
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Target | Alpha-1D adrenergic receptor |
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Ligand | BDBM50082784 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_32453 (CHEMBL643401) |
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Ki | 340±n/a nM |
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Citation | Lagu, B; Tian, D; Nagarathnam, D; Marzabadi, MR; Wong, WC; Miao, SW; Zhang, F; Sun, W; Chiu, G; Fang, J; Forray, C; Chang, RS; Ransom, RW; Chen, TB; O'Malley, S; Zhang, K; Vyas, KP; Gluchowski, C Design and synthesis of novel alpha(1)(a) adrenoceptor-selective antagonists. 3. Approaches to eliminate opioid agonist metabolites by using substituted phenylpiperazine side chains. J Med Chem42:4794-803 (1999) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Alpha-1D adrenergic receptor |
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Name: | Alpha-1D adrenergic receptor |
Synonyms: | ADA1D_HUMAN | ADRA1A | ADRA1D | Adrenergic receptor | Adrenergic receptor alpha | Alpha 1D-adrenoceptor | Alpha 1D-adrenoreceptor | Alpha adrenergic receptor (1a and 1d) | Alpha-1D adrenoceptor | Alpha-adrenergic receptor 1a | adrenergic Alpha1D |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 60485.82 |
Organism: | Homo sapiens (Human) |
Description: | adrenergic Alpha1D ADRA1D HUMAN::P25100 |
Residue: | 572 |
Sequence: | MTFRDLLSVSFEGPRPDSSAGGSSAGGGGGSAGGAAPSEGPAVGGVPGGAGGGGGVVGAG
SGEDNRSSAGEPGSAGAGGDVNGTAAVGGLVVSAQGVGVGVFLAAFILMAVAGNLLVILS
VACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATMEVLGFWAFGRAFCDVWAAVDVLCC
TASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWVVALVVSVGPLLGWKEPVP
PDERFCGITEEAGYAVFSSVCSFYLPMAVIVVMYCRVYVVARSTTRSLEAGVKRERGKAS
EVVLRIHCRGAATGADGAHGMRSAKGHTFRSSLSVRLLKFSREKKAAKTLAIVVGVFVLC
WFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQ
CRRRRRRRPLWRVYGHHWRASTSGLRQDCAPSSGDAPPGAPLALTALPDPDPEPPGTPEM
QAPVASRRKPPSAFREWRLLGPFRRPTTQLRAKVSSLSHKIRAGGAQRAEAACAQRSEVE
AVSLGVPHEVAEGATCQAYELADYSNLRETDI
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BDBM50082784 |
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n/a |
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Name | BDBM50082784 |
Synonyms: | 1-(3-{[5-Carbamoyl-6-(3,4-difluoro-phenyl)-4-ethyl-2-oxo-3,6-dihydro-2H-pyrimidine-1-carbonyl]-amino}-propyl)-4-phenyl-piperidine-4-carboxylic acid methyl ester | CHEMBL356584 |
Type | Small organic molecule |
Emp. Form. | C30H35F2N5O5 |
Mol. Mass. | 583.6262 |
SMILES | CCC1=C(C(N(C(=O)NCCCN2CCC(CC2)(C(=O)OC)c2ccccc2)C(=O)N1)c1ccc(F)c(F)c1)C(N)=O |t:2| |
Structure |
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