| Reaction Details |
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 | Report a problem with these data |
| Target | Cysteine protease ATG4B |
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| Ligand | BDBM50528274 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1904761 (CHEMBL4407119) |
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| IC50 | 113000±n/a nM |
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| Citation |  Quintana, M; Bilbao, A; Comas-Barceló, J; Bujons, J; Triola, G Identification of benzo[cd]indol-2(1H)-ones as novel Atg4B inhibitors via a structure-based virtual screening and a novel AlphaScreen assay. Eur J Med Chem178:648-666 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cysteine protease ATG4B |
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| Name: | Cysteine protease ATG4B |
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| Synonyms: | APG4B | ATG4B | ATG4B_HUMAN | AUTL1 | KIAA0943 | cysteine protease ATG4B isoform a | hck |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 44279.79 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_47132611 |
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| Residue: | 393 |
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| Sequence: | MDAATLTYDTLRFAEFEDFPETSEPVWILGRKYSIFTEKDEILSDVASRLWFTYRKNFPA
IGGTGPTSDTGWGCMLRCGQMIFAQALVCRHLGRDWRWTQRKRQPDSYFSVLNAFIDRKD
SYYSIHQIAQMGVGEGKSIGQWYGPNTVAQVLKKLAVFDTWSSLAVHIAMDNTVVMEEIR
RLCRTSVPCAGATAFPADSDRHCNGFPAGAEVTNRPSPWRPLVLLIPLRLGLTDINEAYV
ETLKHCFMMPQSLGVIGGKPNSAHYFIGYVGEELIYLDPHTTQPAVEPTDGCFIPDESFH
CQHPPCRMSIAELDPSIAVGFFCKTEDDFNDWCQQVKKLSLLGGALPMFELVELQPSHLA
CPDVLNLSLDSSDVERLERFFDSEDEDFEILSL
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| BDBM50528274 |
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| n/a |
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| Name | BDBM50528274 |
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| Synonyms: | CHEMBL4573305 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H16N2O2 |
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| Mol. Mass. | 256.2997 |
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| SMILES | CC[C@H](O)CNc1cc2C(=O)Nc3cccc(c1)c23 |r| |
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| Structure | 
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