Reaction Details | |||
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Target | Biotin carboxylase | ||
Ligand | BDBM3429 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1905195 (CHEMBL4407553) | ||
IC50 | 320±n/a nM | ||
Citation | Andrews, LD; Kane, TR; Dozzo, P; Haglund, CM; Hilderbrandt, DJ; Linsell, MS; Machajewski, T; McEnroe, G; Serio, AW; Wlasichuk, KB; Neau, DB; Pakhomova, S; Waldrop, GL; Sharp, M; Pogliano, J; Cirz, RT; Cohen, F Optimization and Mechanistic Characterization of Pyridopyrimidine Inhibitors of Bacterial Biotin Carboxylase. J Med Chem62:7489-7505 (2019) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Biotin carboxylase | |||
Name: | Biotin carboxylase | ||
Synonyms: | 6.3.4.14 | 6.4.1.2 | ACC | ACCC_PSEAE | Acetyl-CoA carboxylase subunit A | Biotin carboxylase | accC | fabG | fabG | ||
Type: | PROTEIN | ||
Mol. Mass.: | 48885.33 | ||
Organism: | Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM14847 / LMG 12228 / 1C / PRS 101 / PAO1) | ||
Description: | ChEMBL_118971 | ||
Residue: | 449 | ||
Sequence: |
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BDBM3429 | |||
n/a | |||
Name | BDBM3429 | ||
Synonyms: | 6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidine-2,7-diamine | 6-arylpyrido[2,3-d]pyrimidine deriv. 11 | ||
Type | Small organic molecule | ||
Emp. Form. | C13H9Cl2N5 | ||
Mol. Mass. | 306.15 | ||
SMILES | Nc1ncc2cc(c(N)nc2n1)-c1c(Cl)cccc1Cl |(-6.11,.68,;-4.78,1.45,;-4.78,2.99,;-3.44,3.76,;-2.11,2.99,;-.77,3.76,;.56,2.99,;.56,1.45,;1.89,.68,;-.77,.68,;-2.11,1.45,;-3.44,.68,;1.89,3.76,;1.89,5.3,;.56,6.07,;3.23,6.07,;4.56,5.3,;4.56,3.76,;3.23,2.99,;3.23,1.45,)| | ||
Structure |