| Reaction Details |
|---|
 | Report a problem with these data |
| Target | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic |
|---|
| Ligand | BDBM50528590 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1905458 (CHEMBL4407816) |
|---|
| IC50 | 32±n/a nM |
|---|
| Citation |  Lienau, C; Gräwert, T; Alves Avelar, LA; Illarionov, B; Held, J; Knaab, TC; Lungerich, B; van Geelen, L; Meier, D; Geissler, S; Cynis, H; Riederer, U; Buchholz, M; Kalscheuer, R; Bacher, A; Mordmüller, B; Fischer, M; Kurz, T Novel reverse thia-analogs of fosmidomycin: Synthesis and antiplasmodial activity. Eur J Med Chem181:0 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic |
|---|
| Name: | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic |
|---|
| Synonyms: | 1-deoxyxylulose-5-phosphate reductoisomerase | DOXP reductoisomerase | DXP reductoisomerase | DXR | DXR_PLAF7 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 55772.75 |
|---|
| Organism: | Plasmodium falciparum (isolate 3D7) |
|---|
| Description: | ChEMBL_117864 |
|---|
| Residue: | 488 |
|---|
| Sequence: | MKKYIYIYFFFITITINDLVINNTSKCVSIERRKNNAYINYGIGYNGPDNKITKSRRCKR
IKLCKKDLIDIGAIKKPINVAIFGSTGSIGTNALNIIRECNKIENVFNVKALYVNKSVNE
LYEQAREFLPEYLCIHDKSVYEELKELVKNIKDYKPIILCGDEGMKEICSSNSIDKIVIG
IDSFQGLYSTMYAIMNNKIVALANKESIVSAGFFLKKLLNIHKNAKIIPVDSEHSAIFQC
LDNNKVLKTKCLQDNFSKINNINKIFLCSSGGPFQNLTMDELKNVTSENALKHPKWKMGK
KITIDSATMMNKGLEVIETHFLFDVDYNDIEVIVHKECIIHSCVEFIDKSVISQMYYPDM
QIPILYSLTWPDRIKTNLKPLDLAQVSTLTFHKPSLEHFPCIKLAYQAGIKGNFYPTVLN
ASNEIANNLFLNNKIKYFDISSIISQVLESFNSQKVSENSEDLMKQILQIHSWAKDKATD
IYNKHNSS
|
|
|
|---|
| BDBM50528590 |
|---|
| n/a |
|---|
| Name | BDBM50528590 |
|---|
| Synonyms: | CHEMBL4447571 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C10H14NO5PS |
|---|
| Mol. Mass. | 291.261 |
|---|
| SMILES | Cc1ccc(cc1)C(SCC(=O)NO)P(O)(O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
