| Reaction Details |
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 | Report a problem with these data |
| Target | Liver carboxylesterase |
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| Ligand | BDBM50130915 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1907446 (CHEMBL4409804) |
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| IC50 | 1800±n/a nM |
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| Citation |  Khudina, OG; Makhaeva, GF; Elkina, NA; Boltneva, NP; Serebryakova, OG; Shchegolkov, EV; Rudakova, EV; Lushchekina, SV; Burgart, YV; Bachurin, SO; Richardson, RJ; Saloutin, VI Synthesis of 2-arylhydrazinylidene-3-oxo-4,4,4-trifluorobutanoic acids as new selective carboxylesterase inhibitors and radical scavengers. Bioorg Med Chem Lett29:0 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Liver carboxylesterase |
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| Name: | Liver carboxylesterase |
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| Synonyms: | Carboxylesterase | EST1_PIG |
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| Type: | PROTEIN |
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| Mol. Mass.: | 62009.98 |
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| Organism: | Sus scrofa |
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| Description: | ChEMBL_427761 |
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| Residue: | 566 |
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| Sequence: | MWLLPLVLTSLASSATWAGQPASPPVVDTAQGRVLGKYVSLEGLAQPVAVFLGVPFAKPP
LGSLRFAPPQPAEPWSFVKNTTSYPPMCCQDPVVEQMTSDLFTNGKERLTLEFSEDCLYL
NIYTPADLTKRGRLPVMVWIHGGGLVLGGAPMYDGVVLAAHENVVVVAIQYRLGIWGFFS
TGDEHSRGNWGHLDQVAALHWVQENIANFGGDPGSVTIFGESAGGESVSVLVLSPLAKNL
FHRAISESGVALTVALVRKDMKAAAKQIAVLAGCKTTTSAVFVHCLRQKSEDELLDLTLK
MKFLTLDFHGDQRESHPFLPTVVDGVLLPKMPEEILAEKDFNTVPYIVGINKQEFGWLLP
TMMGFPLSEGKLDQKTATSLLWKSYPIANIPEELTPVATDKYLGGTDDPVKKKDLFLDLM
GDVVFGVPSVTVARQHRDAGAPTYMYEFQYRPSFSSDKKPKTVIGDHGDEIFSVFGFPLL
KGDAPEEEVSLSKTVMKFWANFARSGNPNGEGLPHWPMYDQEEGYLQIGVNTQAAKRLKG
EEVAFWNDLLSKEAAKKPPKIKHAEL
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| BDBM50130915 |
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| n/a |
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| Name | BDBM50130915 |
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| Synonyms: | CHEBI:3122 | CHEMBL1231178 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H9N2O8P |
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| Mol. Mass. | 340.1822 |
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| SMILES | OP(=O)(Oc1ccc(cc1)[N+]([O-])=O)Oc1ccc(cc1)[N+]([O-])=O |
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| Structure | 
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