| Reaction Details |
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 | Report a problem with these data |
| Target | Trypanothione reductase |
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| Ligand | BDBM83820 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_211976 (CHEMBL878025) |
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| Ki | 38000±n/a nM |
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| Citation |  Bonse, S; Santelli-Rouvier, C; Barbe, J; Krauth-Siegel, RL Inhibition of Trypanosoma cruzi trypanothione reductase by acridines: kinetic studies and structure-activity relationships. J Med Chem42:5448-54 (2000) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Trypanothione reductase |
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| Name: | Trypanothione reductase |
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| Synonyms: | N(1),N(8)-bis(glutathionyl)spermidine reductase | TPR | TR | TYTR_TRYCR |
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| Type: | Homodimer; oxidoreductase |
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| Mol. Mass.: | 53868.26 |
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| Organism: | Trypanosoma cruzi |
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| Description: | n/a |
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| Residue: | 492 |
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| Sequence: | MMSKIFDLVVIGAGSGGLEAAWNAATLYKKRVAVIDVQMVHGPPFFSALGGTCVNVGCVP
KKLMVTGAQYMEHLRESAGFGWEFDRTTLRAEWKKLIAVKDEAVLNINKSYEEMFRDTEG
LEFFLGWGSLESKNVVNVRESADPASAVKERLETENILLASGSWPHMPNIPGIEHCISSN
EAFYLPEPPRRVLTVGGGFISVEFAGIFNAYKPKDGQVTLCYRGEMILRGFDHTLREELT
KQLTANGIQILTKENPAKVELNADGSKSVTFESGKKMDFDLVMMAIGRSPRTKDLQLQNA
GVMIKNGGVQVDEYSRTNVSNIYAIGDVTNRVMLTPVAINEAAALVDTVFGTNPRKTDHT
RVASAVFSIPPIGTCGLIEEVASKRYEVVAVYLSSFTPLMHNISGSKYKTFVAKIITNHS
DGTVLGVHLLGDNAPEIIQGVGICLKLNAKISDFYNTIGVHPTSAEELCSMRTPSYYYVK
GEKMEKPSEASL
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| BDBM83820 |
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| n/a |
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| Name | BDBM83820 |
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| Synonyms: | 9-Amino-acridinium | 9-acridin-10-iumamine;chloride | MLS001241050 | SMR000841177 | acridin-10-ium-9-amine;chloride | acridin-10-ium-9-ylamine;chloride | cid_24892261 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H11N2 |
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| Mol. Mass. | 195.2393 |
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| SMILES | Nc1c2ccccc2[nH+]c2ccccc12 |
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| Structure | 
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