| Reaction Details |
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 | Report a problem with these data |
| Target | Mu-type opioid receptor |
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| Ligand | BDBM50045758 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1908760 (CHEMBL4411118) |
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| Ki | 0.100000±n/a nM |
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| Citation |  Long, DD; Armstrong, SR; Beattie, DT; Campbell, CB; Church, TJ; Colson, PJ; Dalziel, SM; Jacobsen, JR; Jiang, L; Obedencio, GP; Rapta, M; Saito, D; Stergiades, I; Tsuruda, PR; Van Dyke, PM; Vickery, RG Discovery of Axelopran (TD-1211): A Peripherally Restricted ?-Opioid Receptor Antagonist. ACS Med Chem Lett10:1641-1647 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mu-type opioid receptor |
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| Name: | Mu-type opioid receptor |
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| Synonyms: | M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 44789.51 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P35372 |
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| Residue: | 400 |
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| Sequence: | MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCP
PTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALAT
STLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDF
RTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFI
FAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHI
YVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNI
EQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
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| BDBM50045758 |
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| n/a |
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| Name | BDBM50045758 |
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| Synonyms: | 3-[3,4-Dimethyl-1-(3-phenyl-propyl)-piperidin-4-yl]-phenol | CHEMBL320218 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H29NO |
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| Mol. Mass. | 323.4718 |
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| SMILES | C[C@H]1CN(CCCc2ccccc2)CC[C@@]1(C)c1cccc(O)c1 |
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| Structure | 
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