| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tyrosinase |
|---|
| Ligand | BDBM50203985 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1908901 (CHEMBL4411347) |
|---|
| IC50 | 70±n/a nM |
|---|
| Citation |  Pillaiyar, T; Namasivayam, V; Manickam, M; Jung, SH Inhibitors of Melanogenesis: An Updated Review. J Med Chem61:7395-7418 (2018) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tyrosinase |
|---|
| Name: | Tyrosinase |
|---|
| Synonyms: | LB24-AB | Monophenol monooxygenase | SK29-AB | TYR | TYRO_HUMAN | Tumor rejection antigen AB |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 60388.08 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P14679 |
|---|
| Residue: | 529 |
|---|
| Sequence: | MLLAVLYCLLWSFQTSAGHFPRACVSSKNLMEKECCPPWSGDRSPCGQLSGRGSCQNILL
SNAPLGPQFPFTGVDDRESWPSVFYNRTCQCSGNFMGFNCGNCKFGFWGPNCTERRLLVR
RNIFDLSAPEKDKFFAYLTLAKHTISSDYVIPIGTYGQMKNGSTPMFNDINIYDLFVWMH
YYVSMDALLGGSEIWRDIDFAHEAPAFLPWHRLFLLRWEQEIQKLTGDENFTIPYWDWRD
AEKCDICTDEYMGGQHPTNPNLLSPASFFSSWQIVCSRLEEYNSHQSLCNGTPEGPLRRN
PGNHDKSRTPRLPSSADVEFCLSLTQYESGSMDKAANFSFRNTLEGFASPLTGIADASQS
SMHNALHIYMNGTMSQVQGSANDPIFLLHHAFVDSIFEQWLRRHRPLQEVYPEANAPIGH
NRESYMVPFIPLYRNGDFFISSKDLGYDYSYLQDSDPDSFQDYIKSYLEQASRIWSWLLG
AAMVGAVLTALLAGLVSLLCRHKRKQLPEEKQPLLMEKEDYHSLYQSHL
|
|
|
|---|
| BDBM50203985 |
|---|
| n/a |
|---|
| Name | BDBM50203985 |
|---|
| Synonyms: | (E)-1-(2,4-dihydroxyphenyl)-3-(2,4-dihydroxyphenyl)-2-propen-1-one (18) | 2,2',4,4'-tetrahydroxychalcone | 2,4,2',4'-tetrahydroxychalcone | CHEMBL394855 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C15H12O5 |
|---|
| Mol. Mass. | 272.2528 |
|---|
| SMILES | Oc1ccc(\C=C\C(=O)c2ccc(O)cc2O)c(O)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
