| Reaction Details |
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 | Report a problem with these data |
| Target | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta |
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| Ligand | BDBM50529737 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1909754 (CHEMBL4412200) |
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| IC50 | 24±n/a nM |
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| Citation |  Chen, D; Chen, Y; Lian, F; Chen, L; Li, Y; Cao, D; Wang, X; Chen, L; Li, J; Meng, T; Huang, M; Geng, M; Shen, J; Zhang, N; Xiong, B Fragment-based drug discovery of triazole inhibitors to block PDE?-RAS protein-protein interaction. Eur J Med Chem163:597-609 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta |
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| Name: | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta |
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| Synonyms: | 3',5'-cyclic phosphodiesterase | GMP-PDE delta | PDE6D | PDE6D_HUMAN | PDED | Protein p17 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta |
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| Type: | PROTEIN |
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| Mol. Mass.: | 17418.30 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_105761 |
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| Residue: | 150 |
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| Sequence: | MSAKDERAREILRGFKLNWMNLRDAETGKILWQGTEDLSVPGVEHEARVPKKILKCKAVS
RELNFSSTEQMEKFRLEQKVYFKGQCLEEWFFEFGFVIPNSTNTWQSLIEAAPESQMMPA
SVLTGNVIIETKFFDDDLLVSTSRVRLFYV
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| BDBM50529737 |
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| n/a |
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| Name | BDBM50529737 |
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| Synonyms: | CHEMBL4459864 |
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| Type | Small organic molecule |
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| Emp. Form. | C31H34N4O3S |
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| Mol. Mass. | 542.692 |
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| SMILES | COc1ccc(CSc2nnc(-c3ccc(OCC(=O)NC4CCCCC4)cc3)n2Cc2ccccc2)cc1 |
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| Structure | 
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