| Reaction Details |
|---|
 | Report a problem with these data |
| Target | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial |
|---|
| Ligand | BDBM50529879 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1910759 (CHEMBL4413205) |
|---|
| IC50 | 8300±n/a nM |
|---|
| Citation |  Wu, DM; Wang, YJ; Fan, SH; Zhang, ZF; Shan, Q; Lu, J; Chen, GQ; Zheng, YL High-throughput screening of novel pyruvate dehydrogenase kinases inhibitors and biological evaluation of their in vitro and in vivo antiproliferative activity. Eur J Med Chem164:252-262 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial |
|---|
| Name: | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial |
|---|
| Synonyms: | PDHK3 | PDK3 | PDK3_HUMAN | Pyruvate dehydrogenase kinase | Pyruvate dehydrogenase kinase 3 (PDK3) | Pyruvate dehydrogenase kinase isoform 3 | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 46944.89 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q15120 |
|---|
| Residue: | 406 |
|---|
| Sequence: | MRLFRWLLKQPVPKQIERYSRFSPSPLSIKQFLDFGRDNACEKTSYMFLRKELPVRLANT
MREVNLLPDNLLNRPSVGLVQSWYMQSFLELLEYENKSPEDPQVLDNFLQVLIKVRNRHN
DVVPTMAQGVIEYKEKFGFDPFISTNIQYFLDRFYTNRISFRMLINQHTLLFGGDTNPVH
PKHIGSIDPTCNVADVVKDAYETAKMLCEQYYLVAPELEVEEFNAKAPDKPIQVVYVPSH
LFHMLFELFKNSMRATVELYEDRKEGYPAVKTLVTLGKEDLSIKISDLGGGVPLRKIDRL
FNYMYSTAPRPSLEPTRAAPLAGFGYGLPISRLYARYFQGDLKLYSMEGVGTDAVIYLKA
LSSESFERLPVFNKSAWRHYKTTPEADDWSNPSSEPRDASKYKAKQ
|
|
|
|---|
| BDBM50529879 |
|---|
| n/a |
|---|
| Name | BDBM50529879 |
|---|
| Synonyms: | CHEMBL4434775 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H24N4OS2 |
|---|
| Mol. Mass. | 364.529 |
|---|
| SMILES | C[C@H]1CCc2c(C1)sc1nc(SCCN3CCCC3)n(N)c(=O)c21 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
