| Reaction Details |
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 | Report a problem with these data |
| Target | Casein kinase II subunit alpha 3 |
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| Ligand | BDBM50530315 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1911737 (CHEMBL4414183) |
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| EC50 | 9000±n/a nM |
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| Citation |  Bestgen, B; Kufareva, I; Seetoh, W; Abell, C; Hartmann, RW; Abagyan, R; Le Borgne, M; Filhol, O; Cochet, C; Lomberget, T; Engel, M 2-Aminothiazole Derivatives as Selective Allosteric Modulators of the Protein Kinase CK2. 2. Structure-Based Optimization and Investigation of Effects Specific to the Allosteric Mode of Action. J Med Chem62:1817-1836 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Casein kinase II subunit alpha 3 |
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| Name: | Casein kinase II subunit alpha 3 |
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| Synonyms: | 2.7.11.1 | CK II alpha 3 | CSK23_HUMAN | CSNK2A1P | CSNK2A3 | Casein kinase II alpha 1 polypeptide pseudogene | Casein kinase II subunit alpha 3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 45229.76 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_116899 |
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| Residue: | 391 |
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| Sequence: | MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINIT
NNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTD
FKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE
FYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWRLGCMLASMIFRKEPFFHGRDNYD
QLVRIAKFLGTEDLYGYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDF
LDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANVMSGISSVPT
PSPLGPLAGSPVIAAANPLGMPVPAATGAQQ
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| BDBM50530315 |
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| n/a |
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| Name | BDBM50530315 |
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| Synonyms: | CHEMBL4520531 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H14N2O3S |
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| Mol. Mass. | 362.402 |
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| SMILES | OC(=O)c1ccc(Nc2nc(cs2)-c2ccc3ccccc3c2)cc1O |
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| Structure | 
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