| Reaction Details |
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 | Report a problem with these data |
| Target | Casein kinase II subunit alpha |
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| Ligand | BDBM165207 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1911827 (CHEMBL4414273) |
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| IC50 | 14±n/a nM |
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| Citation |  Bestgen, B; Krimm, I; Kufareva, I; Kamal, AAM; Seetoh, WG; Abell, C; Hartmann, RW; Abagyan, R; Cochet, C; Le Borgne, M; Engel, M; Lomberget, T 2-Aminothiazole Derivatives as Selective Allosteric Modulators of the Protein Kinase CK2. 1. Identification of an Allosteric Binding Site. J Med Chem62:1803-1816 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Casein kinase II subunit alpha |
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| Name: | Casein kinase II subunit alpha |
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| Synonyms: | CK II | CK2 | CK2- alpha | CK2A1 | CSK21_HUMAN | CSNK2A1 | Casein kinase 2 | Casein kinase II (CK2) | Casein kinase II alpha/beta | Casein kinase II subunit alpha (CK2 alpha) | Casein kinase II subunit alpha (CK2A1) | Casein kinase II subunit alpha (CK2a I174A) | Casein kinase II subunit alpha (CK2a V66A) | Casein kinase II subunit alpha (CK2a dm V66I174AA) | Casein kinase II subunit alpha (CK2a) |
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| Type: | Enzyme |
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| Mol. Mass.: | 45151.12 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P68400 |
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| Residue: | 391 |
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| Sequence: | MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINIT
NNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTD
FKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE
FYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYD
QLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDF
LDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPT
PSPLGPLAGSPVIAAANPLGMPVPAAAGAQQ
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| BDBM165207 |
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| n/a |
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| Name | BDBM165207 |
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| Synonyms: | US8168651, Compound TABLE 16.1 | US9062043, Table 10, Compound 10 | US9062043, Table 13, Compound 1 | US9062043, Table 20b, Compound 1 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H13N3O2 |
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| Mol. Mass. | 315.3254 |
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| SMILES | OC(=O)c1ccc2c(c1)nc(Nc1ccccc1)c1ccncc21 |
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| Structure | 
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