Reaction Details |
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Target | Non-receptor tyrosine-protein kinase TYK2 [5-1181] |
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Ligand | BDBM50530383 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1912217 (CHEMBL4414800) |
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IC50 | 83±n/a nM |
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Citation | Moslin, R; Zhang, Y; Wrobleski, ST; Lin, S; Mertzman, M; Spergel, S; Tokarski, JS; Strnad, J; Gillooly, K; McIntyre, KW; Zupa-Fernandez, A; Cheng, L; Sun, H; Chaudhry, C; Huang, C; D'Arienzo, C; Heimrich, E; Yang, X; Muckelbauer, JK; Chang, C; Tredup, J; Mulligan, D; Xie, D; Aranibar, N; Chiney, M; Burke, JR; Lombardo, L; Carter, PH; Weinstein, DS Identification of J Med Chem62:8953-8972 (2019) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Non-receptor tyrosine-protein kinase TYK2 [5-1181] |
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Name: | Non-receptor tyrosine-protein kinase TYK2 [5-1181] |
Synonyms: | Non-receptor tyrosine-protein kinase TYK2 | TYK2_MOUSE | Tyk2 |
Type: | PROTEIN |
Mol. Mass.: | 132654.63 |
Organism: | Mus musculus |
Description: | ChEMBL_105608 |
Residue: | 1177 |
Sequence: | MPLCGRRAILEDSKADGTEAQPLVPTGCLMVLLHWPGPEGGEPWVTFSQTSLTAEEVCIH
IAHKVGITPPCLNLFALYNAQAKVWLPPNHILDTSQDMNLYFRMRFYFRNWHGMNPQEPA
VYRCGFPGAETSSDRAEQGVQLLDSASFEYLFEQGKHEFMNDVVSLRDLSSEEEIHHFKN
ESLGMAFLHLCHLALSRGVPLEEMAREISFKNCIPHSFRQHIRQHNVLTRLRLHRVFRRF
LRAFRPGHLSQQVVMVKYLATLERLAPRFGSERIPVCHLEVLAQPERDPCYIQNSGQTAG
DPGPELPSGPPTHEVLVTGTGGIQWHPLQTQESERGNSRGNPHGSRSGKKPKAPKAGEHL
TESPQEPPWTYFCDFQDISHVVLKERRVHIHLQDNKCLLLCLCSQAEALSFVALVDGYFR
LTADSSHYLCHEVAPPRLVTSIQNGIHGPLMDPFVQAKLWPEDGLYLIQWSTSHLHRLIL
TVAHRNPAFSNGPRGLRLRKFPITQQPGAFVLDGWGRSFASLGDLRLALQGCSLRAGDDC
FPLHHCCLPRPREISNLVIMRGSRAHTRPLNLSQLSFHRVHQDEITQLSHLGQGTRTNVY
EGLLRVGGPDEGKVDNGCPPEPGGTSGQQLRVVLKVLDPSHHDIALAFYETASLMSQVSH
MHLAFLHGVCVRGSENIIVTEFVEHGPLDVWLRRQRGQVPMTWKMVVAQQLASALSYLED
KNLVHGNVCGRNILLARLGLEEGTNPFIKLSDPGVGQGALSREERVERIPWTAPECLSGG
TSSLGTATDMWGFGATLLEICFDGEAPLQGRGPSEKERFYTKKHQLPEPSSPELATLTRQ
CLTYEPAQRPSFRTILRDLTRLQPQNLVGTSAVNSDSPASDPTVFHKRYLKKIRDLGEGH
FGKVSLYCYDPTNDGTGEMVAVKALKEGCGPQLRSGWQREIEILRTLYHEHIVKYKGCCE
DQGEKSVQLVMEYVPLGSLRDYLPRHCVGLAQLLLFAQQICEGMAYLHAQHYIHRDLAAR
NVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKECKFYYASDVWSF
GVTLYELLTYCDSNQSPHMKFTELIGHTQGQMTVLRLTELLERGERLPRPDRCPCEIYHL
MKNCWETEASFRPTFQNLVPILQTAQEKYQGQVPSVF
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BDBM50530383 |
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n/a |
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Name | BDBM50530383 |
Synonyms: | CHEMBL4530719 |
Type | Small organic molecule |
Emp. Form. | C18H16FN5O3S |
Mol. Mass. | 401.415 |
SMILES | CS(=O)(=O)c1ccccc1Nc1cc(Nc2ccc(F)cn2)ncc1C(N)=O |
Structure |
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