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Target3-oxo-5-alpha-steroid 4-dehydrogenase 1
LigandBDBM50032771
Substrate/Competitorn/a
Meas. Tech.ChEBML_205057
IC50 0.500000±n/a nM
Citation Guarna, AOcchiato, EGScarpi, DZorn, CDanza, GComerci, AMancina, RSerio, M Synthesis of 8-chloro-benzo[c]quinolizin-3-ones as potent and selective inhibitors of human steroid 5alpha-reductase 1. Bioorg Med Chem Lett10:353-6 (2000) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
3-oxo-5-alpha-steroid 4-dehydrogenase 1
Name:3-oxo-5-alpha-steroid 4-dehydrogenase 1
Synonyms:3-oxo-5-alpha-steroid 4-dehydrogenase 1 | 5α-Reductase 1 (5α-R1) | S5A1_HUMAN | S5AR | SR type 1 | SRD5A1 | Steroid 5-alpha-reductase | Steroid 5-alpha-reductase 1
Type:Enzyme
Mol. Mass.:29472.80
Organism:Homo sapiens (Human)
Description:P18405
Residue:259
Sequence:
MATATGVAEERLLAALAYLQCAVGCAVFARNRQTNSVYGRHALPSHRLRVPARAAWVVQE
LPSLALPLYQYASESAPRLRSAPNCILLAMFLVHYGHRCLIYPFLMRGGKPMPLLACTMA
IMFCTCNGYLQSRYLSHCAVYADDWVTDPRFLIGFGLWLTGMLINIHSDHILRNLRKPGD
TGYKIPRGGLFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFCFLSGRAKEHHEWY
LRKFEEYPKFRKIIIPFLF
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  Blast E-value cutoff:
BDBM50032771
n/a
NameBDBM50032771
Synonyms:(4aR,6aR,10S)-7-(1,5-Dimethyl-hexyl)-1,4a,6a,10-tetramethyl-hexadecahydro-indeno[5,4-f]quinolin-2-one | (4aR,6aR,7R,10S)-7-(1,5-Dimethyl-hexyl)-1,4a,6a,10-tetramethyl-hexadecahydro-indeno[5,4-f]quinolin-2-one | CHEMBL25448 | MK-386
TypeSmall organic molecule
Emp. Form.C28H49NO
Mol. Mass.415.6948
SMILESCC(C)CCCC(C)C1CCC2C3[C@@H](C)CC4N(C)C(=O)CC[C@]4(C)C3CC[C@]12C
Structure
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