Ki Summary

Reaction Details

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Target

Gonadotropin-releasing hormone receptor

Ligand

BDBM50085807

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_71743 (CHEMBL680265)

0.12±n/a nM

Citation

Rivier, JE; Jiang, G; Struthers, RS; Koerber, SC; Porter, J; Cervini, LA; Kirby, DA; Craig, AG; Rivier, CL Design of potent dicyclic (1-5/4-10) gonadotropin releasing hormone (GnRH) antagonists. J Med Chem43:807-18 (2000) [PubMed]

More Info.:

Get all data from this article, Assay Method

Gonadotropin-releasing hormone receptor

Name:

Gonadotropin-releasing hormone receptor

Synonyms:

GNRHR_RAT | GnRH receptor | GnRH-R | Gnrhr

Type:

PROTEIN

Mol. Mass.:

37767.60

Organism:

Rattus norvegicus

Description:

ChEMBL_1335047

Residue:

327

Sequence:

MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKL
QRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYL
KLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRM
IYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRV
LHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVS
EPVNHFFFLFAFLNPCFDPLIYGYFSL

BDBM50085807

n/a

Name

BDBM50085807

Synonyms:

CHEMBL425966 | Gonadotropin Releasing Hormone analogue

Type

Small organic molecule

Emp. Form.

C67H87FN18O14

Mol. Mass.

1387.5183

SMILES

CC(C)C[C@@H]1NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]2CCC(=O)NCC(=O)NCC[C@@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)NC(CNC(=O)C[C@H](NC(=O)[C@@H](Cc1cccnc1)NC(=O)[C@H](Cc1ccc(F)cc1)NC(=O)[C@@H](Cc1ccc3ccccc3c1)NC(C)=O)C(=O)N2)C(N)=O

Structure