| Reaction Details |
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 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 1D |
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| Ligand | BDBM50086103 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1975 (CHEMBL617580) |
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| IC50 | 667±n/a nM |
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| Citation |  Matzen, L; van Amsterdam, C; Rautenberg, W; Greiner, HE; Harting, J; Seyfried, CA; Böttcher, H 5-HT reuptake inhibitors with 5-HT(1B/1D) antagonistic activity: a new approach toward efficient antidepressants. J Med Chem43:1149-57 (2000) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| 5-hydroxytryptamine receptor 1D |
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| Name: | 5-hydroxytryptamine receptor 1D |
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| Synonyms: | 5-HT-1D | 5-HT1D | 5-hydroxytryptamine receptor 1D | 5HT1D_RAT | Htr1d | Serotonin 1 (5-HT1) receptor | Serotonin 1B/1D receptor | Serotonin receptor 1D |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 41551.75 |
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| Organism: | RAT |
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| Description: | 5-HT1D HTR1D RAT::P28565 |
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| Residue: | 374 |
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| Sequence: | MSLPNQSLEGLPQEASNRSLNATGAWDPEVLQALRISLVVVLSIITLATVLSNAFVLTTI
LLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDITCCT
ASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWAISICISIPPLFWRQATAHE
EMSDCLVNTSQISYTIYSTCGAFYIPSILLIILYGRIYVAARSRILNPPSLYGKRFTTAQ
LITGSAGSSLCSLNPSLHESHTHTVGSPLFFNQVKIKLADSILERKRISAARERKATKTL
GIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPVIYTVFNEDF
RQAFQRVVHFRKAS
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| BDBM50086103 |
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| n/a |
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| Name | BDBM50086103 |
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| Synonyms: | 8-Fluoro-1,3,4,5-tetrahydro-pyrido[4,3-b]indole-2-carboxylic acid [4-methoxy-3-(4-methyl-piperazin-1-yl)-phenyl]-amide | CHEMBL15808 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H28FN5O2 |
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| Mol. Mass. | 437.5098 |
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| SMILES | COc1ccc(NC(=O)N2CCc3[nH]c4ccc(F)cc4c3C2)cc1N1CCN(C)CC1 |
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| Structure | 
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