| Reaction Details |
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 | Report a problem with these data |
| Target | Glutamate receptor ionotropic, NMDA 2C |
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| Ligand | BDBM50086378 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_143328 |
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| IC50 | >100000±n/a nM |
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| Citation |  Gregory, TF; Wright, JL; Wise, LD; Meltzer, LT; Serpa, KA; Konkoy, CS; Whittemore, ER; Woodward, RM Parallel synthesis of a series of subtype-selective NMDA receptor antagonists. Bioorg Med Chem Lett10:527-9 (2000) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Glutamate receptor ionotropic, NMDA 2C |
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| Name: | Glutamate receptor ionotropic, NMDA 2C |
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| Synonyms: | GRIN2C | Glutamate [NMDA] receptor subunit epsilon 3 | Ionotropic glutamate receptor NMDA 1/2C | NMDAR2C | NMDE3_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 134240.15 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_143328 |
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| Residue: | 1233 |
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| Sequence: | MGGALGPALLLTSLFGAWAGLGPGQGEQGMTVAVVFSSSGPPQAQFRARLTPQSFLDLPL
EIQPLTVGVNTTNPSSLLTQICGLLGAAHVHGIVFEDNVDTEAVAQILDFISSQTHVPIL
SISGGSAVVLTPKEPGSAFLQLGVSLEQQLQVLFKVLEEYDWSAFAVITSLHPGHALFLE
GVRAVADASHVSWRLLDVVTLELGPGGPRARTQRLLRQLDAPVFVAYCSREEAEVLFAEA
AQAGLVGPGHVWLVPNLALGSTDAPPATFPVGLISVVTESWRLSLRQKVRDGVAILALGA
HSYWRQHGTLPAPAGDCRVHPGPVSPAREAFYRHLLNVTWEGRDFSFSPGGYLVQPTMVV
IALNRHRLWEMVGRWEHGVLYMKYPVWPRYSASLQPVVDSRHLTVATLEERPFVIVESPD
PGTGGCVPNTVPCRRQSNHTFSSGDVAPYTKLCCKGFCIDILKKLARVVKFSYDLYLVTN
GKHGKRVRGVWNGMIGEVYYKRADMAIGSLTINEERSEIVDFSVPFVETGISVMVARSNG
TVSPSAFLEPYSPAVWVMMFVMCLTVVAITVFMFEYFSPVSYNQNLTRGKKSGGPAFTIG
KSVWLLWALVFNNSVPIENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEQYIDTV
SGLSDKKFQRPQDQYPPFRFGTVPNGSTERNIRSNYRDMHTHMVKFNQRSVEDALTSLKM
GKLDAFIYDAAVLNYMAGKDEGCKLVTIGSGKVFATTGYGIAMQKDSHWKRAIDLALLQF
LGDGETQKLETVWLSGICQNEKNEVMSSKLDIDNMAGVFYMLLVAMGLALLVFAWEHLVY
WKLRHSVPNSSQLDFLLAFSRGIYSCFSGVQSLASPPRQASPDLTASSAQASVLKMLQAA
RDMVTTAGVSSSLDRATRTIENWGGGRRAPPPSPCPTPRSGPSPCLPTPDPPPEPSPTGW
GPPDGGRAALVRRAPQPPGRPPTPGPPLSDVSRVSRRPAWEARWPVRTGHCGRHLSASER
PLSPARCHYSSFPRADRSGRPFLPLFPELEDLPLLGPEQLARREALLHAAWARGSRPRHA
SLPSSVAEAFARPSSLPAGCTGPACARPDGHSACRRLAQAQSMCLPIYREACQEGEQAGA
PAWQHRQHVCLHAHAHLPFCWGAVCPHLPPCASHGSWLSGAWGPLGHRGRTLGLGTGYRD
SGGLDEISRVARGTQGFPGPCTWRRISSLESEV
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| BDBM50086378 |
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| n/a |
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| Name | BDBM50086378 |
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| Synonyms: | 2-[2-(4-Benzyl-piperidin-1-yl)-ethylsulfanyl]-3H-imidazo[4,5-b]pyridine | CHEMBL150641 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H24N4S |
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| Mol. Mass. | 352.496 |
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| SMILES | C(CN1CCC(Cc2ccccc2)CC1)Sc1nc2ncccc2[nH]1 |
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| Structure | 
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