| Reaction Details |
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 | Report a problem with these data |
| Target | Mineralocorticoid receptor |
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| Ligand | BDBM50531580 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1920445 (CHEMBL4423290) |
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| Ki | 10.0±n/a nM |
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| Citation |  Granberg, KL; Yuan, ZQ; Lindmark, B; Edman, K; Kajanus, J; Hogner, A; Malmgren, M; O'Mahony, G; Nordqvist, A; Lindberg, J; Tångefjord, S; Kossenjans, M; Löfberg, C; Brånalt, J; Liu, D; Selmi, N; Nikitidis, G; Nordberg, P; Hayen, A; Aagaard, A; Hansson, E; Hermansson, M; Ivarsson, I; Jansson-Löfmark, R; Karlsson, U; Johansson, U; William-Olsson, L; Hartleib-Geschwindner, J; Bamberg, K Identification of Mineralocorticoid Receptor Modulators with Low Impact on Electrolyte Homeostasis but Maintained Organ Protection. J Med Chem62:1385-1406 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mineralocorticoid receptor |
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| Name: | Mineralocorticoid receptor |
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| Synonyms: | MCR | MCR_HUMAN | MLR | MR | NR3C2 | Nuclear receptor subfamily 3 group C member 2 |
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| Type: | Enzyme |
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| Mol. Mass.: | 107076.42 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P08235 |
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| Residue: | 984 |
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| Sequence: | METKGYHSLPEGLDMERRWGQVSQAVERSSLGPTERTDENNYMEIVNVSCVSGAIPNNST
QGSSKEKQELLPCLQQDNNRPGILTSDIKTELESKELSATVAESMGLYMDSVRDADYSYE
QQNQQGSMSPAKIYQNVEQLVKFYKGNGHRPSTLSCVNTPLRSFMSDSGSSVNGGVMRAV
VKSPIMCHEKSPSVCSPLNMTSSVCSPAGINSVSSTTASFGSFPVHSPITQGTPLTCSPN
VENRGSRSHSPAHASNVGSPLSSPLSSMKSSISSPPSHCSVKSPVSSPNNVTLRSSVSSP
ANINNSRCSVSSPSNTNNRSTLSSPAASTVGSICSPVNNAFSYTASGTSAGSSTLRDVVP
SPDTQEKGAQEVPFPKTEEVESAISNGVTGQLNIVQYIKPEPDGAFSSSCLGGNSKINSD
SSFSVPIKQESTKHSCSGTSFKGNPTVNPFPFMDGSYFSFMDDKDYYSLSGILGPPVPGF
DGNCEGSGFPVGIKQEPDDGSYYPEASIPSSAIVGVNSGGQSFHYRIGAQGTISLSRSAR
DQSFQHLSSFPPVNTLVESWKSHGDLSSRRSDGYPVLEYIPENVSSSTLRSVSTGSSRPS
KICLVCGDEASGCHYGVVTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRL
QKCLQAGMNLGARKSKKLGKLKGIHEEQPQQQQPPPPPPPPQSPEEGTTYIAPAKEPSVN
TALVPQLSTISRALTPSPVMVLENIEPEIVYAGYDSSKPDTAENLLSTLNRLAGKQMIQV
VKWAKVLPGFKNLPLEDQITLIQYSWMCLSSFALSWRSYKHTNSQFLYFAPDLVFNEEKM
HQSAMYELCQGMHQISLQFVRLQLTFEEYTIMKVLLLLSTIPKDGLKSQAAFEEMRTNYI
KELRKMVTKCPNNSGQSWQRFYQLTKLLDSMHDLVSDLLEFCFYTFRESHALKVEFPAML
VEIISDQLPKVESGNAKPLYFHRK
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| BDBM50531580 |
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| n/a |
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| Name | BDBM50531580 |
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| Synonyms: | CHEMBL4448501 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H29FN2O5 |
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| Mol. Mass. | 468.5173 |
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| SMILES | OCC[C@H]1COc2cc(F)c(CC3CCCCC3)cc2N1C(=O)c1ccc2OCC(=O)Nc2c1 |r| |
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| Structure | 
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